Results 131 to 140 of about 12,287 (215)

Antibiotics and phages drive region-specific diversity of OmpK36 in Klebsiella pneumoniae

mBio
The Enterobacterales outer membrane is impermeable to many antibiotics, but they can enter the cell via channel proteins, called porins. In Klebsiella pneumoniae, the porin OmpK36 is a major determinant of antibiotic resistance.
Guilhem Royer, Raphaël Laurenceau, Nicolas Cabanel, Benjamin Bardiaux, Karol Melissa Cerdas-Mejías, David Bikard, Isabelle Rosinski-Chupin, Philippe Glaser   +7 more
doaj   +1 more source

Porins of Neisseria Meningitidis

, 2014
Neisseria meningitidis is a Gram-negative diplococcal bacterium responsible for causing septicaemia and meningococcal disease. It is carried commensally in the nasopharyngeal region by ~10% of the general population.
Jennings, Courtney Donaugh
core   +1 more source

Identification of a Coxiella burnetii outer membrane porin required for intracellular replication

Infection and Immunity
Coxiella burnetii is a gram-negative, obligate intracellular pathogen that causes human Q fever. Within host cells, C. burnetii proliferates in a spacious, acidic, lysosome-derived Coxiella-containing vacuole (CCV) by a process that requires the Dot/Icm ...
Zi Yang, Jeffrey K. Duncan-Lowey, Craig R. Roy   +2 more
doaj   +1 more source

Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

Nature Reviews Microbiology, 2019
Julia Vergalli, I. Bodrenko, Muriel Masi, L. Moynié, S. Acosta-Gutiérrez, J. Naismith, A. Davin-Régli, M. Ceccarelli, B. van den Berg, M. Winterhalter, J. Pagés   +10 more
semanticscholar   +1 more source

INDUCTION OF CYTOKINE MRNA EXPRESSION IN U937 CELLS BY SALMONELLA TYPHIMURIUM PORINS IS REGULATED BY DIFFERENT PHOSPHORYLATION PATHWAYS.

, 2005
Lipopolysaccharide (LPS) and porins of Gram-negative outer membranes are the main pathogenic factors implicated in the clinical syndrome of septic shock. The biological activity of porins and LPS are similar, but they occur by different mechanisms.
Mariateresa Vitiello, Anna Longanella, Emilia Galdiero, A. Tortora, M. Vitiello, N. Damiano, Annalisa Tortora, GALDIERO, EMILIA, M. Galdiero, Nicola Damiano, A. Longanella, Marilena Galdiero   +11 more
core   +1 more source

Understanding Drug Permeability in Pseudomonas aeruginosa

Life
Pseudomonas aeruginosa is a Gram-negative bacterium that poses a serious threat to patients with weakened immunity, cystic fibrosis, severe burns, or those in hospitals.
Ishan Ghai
doaj   +1 more source

Interleukin-1 and interleukin-6 gene expression in human monocytes stimulated with Salmonella typhimurium porins

, 1995
The aim of this study was to verify whether Salmonella typhimurium porins can affect the expression of interleukin-1 (IL-1) and interleukin-6 (IL-6) genes.
MARCATILI A, GALDIERO M, GALDIERO F., DONNARUMMA, Giovanna, CIPOLLARO DE L'ERO G   +4 more
core  

Acid exposure induces adaptive resistance in Klebsiella pneumoniae to combination treatment with antibiotics and biofilm-disrupting surgical lavage

Microbiology Spectrum
Surgical irrigation solutions remove bacteria and disrupt biofilms to prevent nosocomial infections. This study evaluated the impact of combined treatment of a biofilm-disrupting lavage solution and antibiotic therapy.
Jordan L. Chirumbolo, Amanda Hutsell, Amar Kosovac, Isabella Ihemis, Melissa J. Whitford, Juliane Nguy, Rowan J. Wolf, Damir Sarajlic, Topher Hunter, Matthew F. Myntti, Terri N. Ellis   +10 more
doaj   +1 more source

Role of Pasteurella multocida, Pasteurella haemolytica and Salmonella typhimurium porins on inducible nitric oxide release by murine macrophages.

, 2000
The aim of this study was to verify whether Pasteurella haemolytica, P. multocida and Salmonella typhimurium porins could affect the inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) release by murine resident peritoneal macrophages
GALDIERO, Massimiliano, MARTONE F., D'ISANTO M., D'ISANTO M, PAGNINI U., PAGNINI, UGO, PALOMBA E, VITIELLO M., PALOMBA E., MARCATILI A, VITIELLO M, MARCATILI A., GALDIERO M   +12 more
core   +1 more source

Antibiotics translocation through porins: an MD study

, 2007
Gram-negative bacteria are protected against external attack by an outer membrane. However, general diffusion porins located in this membrane allow the entry, by simple diffusion, of small molecules and, among them, antibiotics (beta-lactams and ...
Spiga E, CECCARELLI, MATTEO, RUGGERONE, PAOLO   +2 more
core