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Ugeskrift for laeger, 2000 Porphyria cutanea tarda (PCT), the most common porphyria disease, is characterized by blistering and skin fragility of sun-exposed skin. The symptoms are caused by lowered activity of uroporphyrinogen decarboxylase (URO-D) resulting in accumulation of water-soluble porphyrins in the skin. Most PCT cases are sporadic but can be familiar due to mutations
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Therapy of porphyria cutanea tarda
Expert Opinion on Pharmacotherapy, 2005Porphyria cutanea tarda (PCT) is the most common type of porphyria. There is an association of PCT with haemochromatosis, diabetes mellitus and hepatitis C infection. The basis of treatment of PCT consists of three elements: avoidance of triggering factors, iron depletion and porphyrin elimination.
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Seminars in Liver Disease, 1998
Porphyria cutanea tarda (PCT) is a skin disease that results from decreased activity of uroporphyrinogen decarboxylase (UROD). About 80% of patients have the sporadic (type I) form in which UROD deficiency is restricted to the liver. Others have familial (type II) PCT in which mutations in the UROD gene are inherited in an autosomal dominant pattern ...
C, Fritsch +2 more
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Porphyria cutanea tarda (PCT) is a skin disease that results from decreased activity of uroporphyrinogen decarboxylase (UROD). About 80% of patients have the sporadic (type I) form in which UROD deficiency is restricted to the liver. Others have familial (type II) PCT in which mutations in the UROD gene are inherited in an autosomal dominant pattern ...
C, Fritsch +2 more
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HLA and porphyria cutanea tarda
Archives of Dermatological Research, 1980R Enriquez de Salamanca
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Porphyria cutanea tarda and Pregnancy
Dermatologica, 2009A female patient with porphyria cutanea tarda (PCT) clinically cured by a low-dose chloroquine treatment showed neither exacerbation of the disease nor an increased excretion of urinary porphyrins during pregnancy. The role of estrogens and gestagens as clinical manifestation factors of PCT is discussed.
G, Goerz, G, Hammer
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Porphyria cutanea tarda and pregnancy
American Journal of Obstetrics and Gynecology, 1983Porphyria cutanea tarda (PCT) is an inborn error of metabolism. It is one of a family of six genetically distinct porphyrias and is characterized by a disorder of heme synthesis, resulting in the excess accumulation and excretion of uroporphyrins and coproporphyrins.
L V, Baxi +3 more
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Archives of Dermatology, 1958
Introduction Porphyria is thought to be an "inborn error of metabolism" (Garrod, 1923), i. e., of pyrrole metabolism. Quite a number of classifications of porphyria have been described, but among them the best known are those of Waldenstrom (1937) and of Schmid, Schwartz, and Watson (1953, 1954). In order to avoid any confusion the classifications of
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Introduction Porphyria is thought to be an "inborn error of metabolism" (Garrod, 1923), i. e., of pyrrole metabolism. Quite a number of classifications of porphyria have been described, but among them the best known are those of Waldenstrom (1937) and of Schmid, Schwartz, and Watson (1953, 1954). In order to avoid any confusion the classifications of
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DIAZINON AND PORPHYRIA CUTANEA TARDA
Medical Journal of Australia, 1979Cutaneous application of diazinon to rats over a period of 12 weeks gives rise to a condition biochemically indistinguishable from porphyria cutanea tarda. Faecal porphyrin levels are elevated with the appearance of isocoproporphyrin in the faeces. Oral administration of diazinon does not appear to cause any disturbance of porphyrin metabolism.
P, Bleakley, A W, Nichol, A G, Collins
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Causes of Porphyria Cutanea Tarda
Archives of Dermatology, 1977To the Editor.— Porphyria cutanea tarda (PCT) is a disorder with multiple causes, and the liver appears to be the main target organ that regulates the breakdown metabolism of heme. Unfortunately, not all the proven causes are well known, and I was surprised at a recent meeting to hear a well-known expert on porphyrins give only a partial list of ...
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Porphyria cutanea tarda and sarcoidosis
Clinical and Experimental Dermatology, 1982Summary A case of porphyria cutanea tarda and sarcoidosis involving the lungs and liver is described. This appears to he the second case showing such an association reported in the English literature. The relationship between the two conditions and their response to prednisolone is discussed.
R J, Mann, R R, Harman
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