Results 61 to 70 of about 11,286 (212)
Biomedicines, 2022 Heme is a member of the porphyrins family of cyclic tetrapyrroles and influences various cell processes and signalling pathways. Enzyme deficiencies in the heme biosynthetic pathway provoke rare human inherited metabolic diseases called porphyrias ...
Maria Savino +11 more
doaj +1 more source
The photodynamic and non-photodynamic actions of porphyrins
Brazilian Journal of Medical and Biological Research, 1999 Porphyrias are a family of inherited diseases, each associated with a partial defect in one of the enzymes of the heme biosynthetic pathway. In six of the eight porphyrias described, the main clinical manifestation is skin photosensitivity brought about ...
S.G. Afonso +2 more
doaj +1 more source
A family with acute intermittent porphyria [PDF]
, 2008 Porphyrias are inherited defects in heme metabolism that result in excessive secretion of porphyrins and porphyrin precursors. Porphyrias can be classified into acute, (neuropsychiatric), cutaneous and mixed forms.
Billoo, Abdul Gaffar, Lone, Saira Waqar
core +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 6, December 2025.ABSTRACT Gamma‐hydroxybutyric acid (GHB), a potential agent in drug‐facilitated sexual assault, is difficult to detect due to rapid elimination, endogenous presence, and possible postsampling formation. We conducted a randomised, placebo‐controlled trial in 30 healthy volunteers, administering 50‐mg/kg sodium oxybate or placebo, to investigate symptoms,
Kathrine Bohn Faldborg +3 more
wiley +1 more source
Skin Fragility and Hyperpigmentation in a Patient With HIV
JEADV Clinical Practice, EarlyView.
Catalina Retamal +2 more
wiley +1 more source
Journal of Cosmetic Dermatology, Volume 24, Issue 12, December 2025.ABSTRACT Background Cellulite is a common aesthetic condition of the skin, predominantly affecting more than 90% of postpubertal females. Energy‐based devices (EBDs) have demonstrated efficacy in treating a variety of dermatologic concerns. A controlled thermal injury to the dermis can stimulate remodeling of the extracellular matrix (ECM), leading to ...
Michael H. Gold +6 more
wiley +1 more source
Kinetic evaluation of human cloned coproporphyrinogen oxidase using a ring isomer of the natural substrate [PDF]
, 2005 Background: The enzyme coproporphyrinogen oxidase (copro\u27gen oxidase) converts coproporphyrinogen-Ill (GIII) to protoporphyrinogen-IX via an intermediary monovinyl porphyrinogen. The A ring isomer coproporphyrinogen-IV (C-IV) has previously been shown
Cooper, Christopher L +2 more
core +1 more source
A review of photodiagnostic investigations over 26 years:experience of the National Scottish Photobiology Service (1989-2015) [PDF]
, 2017 Background The Scottish Photobiology Service is the national referral pathway for patients with cutaneous photosensitivity diseases in Scotland. We reviewed the pattern of diagnosis of photosensitivity diseases and investigations performed between 1989 ...
Dawe, Robert +3 more
core +3 more sources
Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma
Cancer Medicine, Volume 14, Issue 21, November 2025.ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer‐related deaths worldwide. Despite advancements in antiviral therapies for hepatitis B (HBV) and hepatitis C (HCV), HCC incidence continues to rise due to metabolic dysfunction‐associated steatotic liver disease (MASLD), obesity ...
Muhammad Masroor Hussain +5 more
wiley +1 more source
Presentations associated with porphyrias in intensive care units
Southwest Respiratory and Critical Care Chronicles, 2016 Porphyrias are a group of uncommon congenital metabolic diseases that are difficult to diagnose as they often present with nonspecific symptoms, mimicking other diseases.
Doungporn Ruthirago +2 more
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