Results 81 to 90 of about 40,631 (243)

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Porphyrins with combinations of 4-carboxyphenyl and 4-hydroxyphenyl substituents in meso-positions as anti-HIV-1 agents

Scientific Reports
A series of 4-carboxyphenyl/4-hydroxyphenyl meso-substituted porphyrins were synthesized, purified, and characterized. The compounds exhibited anti-HIV-1 activities, in vitro, under both non-photodynamic (non-PDT) and photodynamic (PDT) conditions ...
Debdulal Sharma, Aradhana Singh, Sanaullah Safi, Ritu Gaur, Devashish Sengupta   +4 more
doaj   +1 more source

Photodynamic therapeutic activities of tri-bromine porphyrins: Effect of nitrogen position on the pyridine

Journal of Photochemistry and Photobiology
This study focuses on the synthesis of tri-bromine containing asymmetric porphyrins for their use as photosensitizers in photodynamic therapy and photodynamic antimicrobial chemotherapy.
Thembani Silas Vukeya, John Mack, Tebello Nyokong   +2 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Greener Solvents for the Photoisomerization and Catalytic Heat Release of a Norbornadiene‐Based Molecular Solar Thermal Energy Storage System

Advanced Science, EarlyView.
A Molecular Solar Thermal (MOST) system combining a scalable norbornadiene–quadricyclane photoswitch, a biodegradable solvent, propylene carbonate, and noble and first‐row metal catalysts, is presented. Propylene carbonate boosts photoisomerization quantum yield by 25% compared to toluene, prolongs energy storage by an additional 15 days, and enables ...
Lucien Magson, Helen Hölzel, Rebecca J. Salthouse, Liang Fei, Pedro Ferreira, Vitor A. S. Almodovar, Kasper Moth‐Poulsen, Ignacio Funes‐Ardoiz, Diego Sampedro   +8 more
wiley   +1 more source

Janus Reactivity of a Mononuclear Non‐Heme Iron(III)‐Peroxo Complex Toward Indole Oxidation

Angewandte Chemie, EarlyView.
The iron(III)‐peroxo complex [FeIII(O2)(12‐TMC)]+ exhibits bifurcating pathways in indole oxidation. N─H indoles undergo N─H H‐atom abstraction, supported by a KIE of 5.2 for N─H/N–D 2,3‐dimethylindoles, whereas N‐methylindoles react via electrophilic addition of the iron‐peroxo group to the C2–C3 double bond of the indole ring, forming iron ...
Wenjuan Zhu, Peng Wu, Binju Wang, Kallol Ray, Wonwoo Nam   +4 more
wiley   +2 more sources

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Second‐Sphere Aromatic Substitutions That Tune H‐Atom Transfer Reactivity Observed for a Series of S = 1 Nonheme FeIV=O Complexes: An Enthalpy‐Entropy Compensation Effect

Angewandte Chemie, EarlyView.
A series of oxoiron(IV) complexes was synthesized to determine the impact of electronically tuned aromatic substitution in the secondary sphere of the ligand. Despite possessing identical electronic properties, they show significant differences in C─H oxidation reactions.
Abhishek Das, Jin Xiong, Victor G. Young Jr., Yisong Guo, Marcel Swart, Lawrence Que Jr.   +5 more
wiley   +2 more sources

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

Hydrogen‐Bonding Order Associated With Radical Delocalization in Layered Organic Cathode Materials

Angewandte Chemie, EarlyView.
“TAQ” and TAPT share the same pyrazine‐based molecular structure but differ in degree of crystallinity. Combined x‐ray scattering, solid‐state NMR, MicroED, and EPR reveal that “TAQ”'s higher crystallinity and ordered hydrogen‐bonding network are associated with enhanced radical delocalization and conductivity, highlighting structural order as a design
Alae Eddine Lakraychi, Zeqian Zhang, Oliver Lin, Eric D Walter, Jiaqi Wang, Harshan Reddy Gopidi, Eliot F. Woods, Ruozhu Feng, Wei Wang, Pieremanuele Canepa, Brett A. Helms, Kamila M. Wiaderek, Qian Chen, Yan Yao, Ying Chen   +14 more
wiley   +2 more sources