Results 11 to 20 of about 78,386 (279)

Porphyromonas gingivalis and Its Systemic Impact: Current Status

Pathogens, 2020
The relationship between periodontitis and systemic diseases, notably including atherosclerosis and diabetes, has been studied for several years. Porphyromonas gingivalis, a prominent component of oral microorganism communities, is the main pathogen that
Feng Mei, Mengru Xie, Xiaofei Huang, Yanlin Long, Xiaofeng Lu, Xiaoli Wang, Lili Chen   +6 more
doaj   +2 more sources

Porphyromonas gingivalis outside the oral cavity

Odontology, 2021
Porphyromonas gingivalis, a Gram-negative anaerobic bacillus present in periodontal disease, is considered one of the major pathogens in periodontitis. A literature search for English original studies, case series and review articles published up to December 2019 was performed using the MEDLINE, PubMed and GoogleScholar databases, with the search terms
Bregaint, Steeve, Boyer, Emile, Fong, Shao Bing, Meuric, Vincent, Bonnaure-Mallet, Martine, Jolivet-Gougeon, Anne   +5 more
openaire   +5 more sources

Possible role of Porphyromonas gingivalis in orodigestive cancers

Journal of Oral Microbiology, 2019
There is increasing evidence for an association between periodontitis/tooth loss and oral, gastrointestinal, and pancreatic cancers. Periodontal disease, which is characterized by chronic inflammation and microbial dysbiosis, is a significant risk factor
Ingar Olsen, Özlem Yilmaz
doaj   +2 more sources

Local and Systemic Effects of Porphyromonas gingivalis Infection

Microorganisms, 2023
Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and ...
William A Chen, Y. Dou, H. Fletcher, D. Boskovic   +3 more
semanticscholar   +1 more source

Porphyromonas gingivalis regulates atherosclerosis through an immune pathway

Frontiers in Immunology, 2023
Atherosclerosis (AS) is a chronic inflammatory disease, involving a pathological process of endothelial dysfunction, lipid deposition, plaque rupture, and arterial occlusion, and is one of the leading causes of death in the world population.
Qijun Ruan, P. Guan, Weijuan Qi, Jiatong Li, Mengying Xi, L. Xiao, S. Zhong, Dandan Ma, J. Ni   +8 more
semanticscholar   +1 more source

Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

International Journal of Oral Science, 2023
Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer’s disease (AD). The blood-brain barrier
S. Lei, Jian Li, Jin-Whan Yu, Fulong Li, Yaping Pan, Xu Chen, Chun-wei Ma, Weidong Zhao, Xiaolin Tang   +8 more
semanticscholar   +1 more source

Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils

Gut microbes, 2022
Intratumor microbiome shapes the immune system and influences the outcome of various tumors. Porphyromonas gingivalis (P. gingivalis), the keystone periodontal pathogen, is highly epidemically connected with pancreatic cancer (PC). However, its causative
Qin Tan, Xiao Ma, Bing-Hu Yang, Ye Liu, Yibin Xie, Xijun Wang, W. Yuan, Jie Ma   +7 more
semanticscholar   +1 more source

Role of Porphyromonas gingivalis in oral and orodigestive squamous cell carcinoma.

Periodontology, 2022
Oral and esophageal squamous cell carcinomas harbor a diverse microbiome that differs compositionally from precancerous and healthy tissues. Though causality is yet to be definitively established, emerging trends implicate periodontal pathogens such as ...
R. Lamont, Z. Fitzsimonds, Huizhi Wang, Shegan Gao   +3 more
semanticscholar   +1 more source

Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice

Frontiers in Cellular and Infection Microbiology, 2022
Background Porphyromonas gingivalis (Pg), the keystone pathogen in chronic periodontitis, is reported to initiate Alzheimer’s disease pathologies in preclinical studies.
Ting Gong, Qi Chen, Hongchen Mao, Yao V. Zhang, Huan Ren, Mengmeng Xu, H. Chen, Deqin Yang   +7 more
semanticscholar   +1 more source

Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases

Pathogens, 2022
Porphyromonas gingivalis is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria.
Lorena Horvat Aleksijević, Marko Aleksijević, I. Škrlec, Marko Šram, M. Šram, J. Talapko   +5 more
semanticscholar   +1 more source