Results 31 to 40 of about 8,404,331 (252)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

A Middle to Late Miocene Trans-Andean Portal: Geologic Record in the Tatacoa Desert

open access: yesFrontiers in Earth Science, 2021
Integration of several geologic lines of evidence reveals the prevalence of a lowland trans-Andean portal communicating western Amazonia and the westernmost Andes from at least middle Miocene until Pliocene times.
C. Montes   +19 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Accelerating AI-Driven Neuroimaging Research in Dementia

open access: yesInternational Journal of Population Data Science
Artificial intelligence (AI) is rapidly advancing neuroimaging research for earlier and more accurate detection of dementia, yet the complexity, size, and heterogeneity of neuroimaging data create substantial barriers to scalable analysis within secure ...
Lewis Hotchkiss   +3 more
doaj   +1 more source

Portal vein thrombosis in patients with liver cirrhosis [PDF]

open access: yesVojnosanitetski Pregled
Background/Aim. Portal vein thrombosis (PVT) in patients with liver cirrhosis (LC) has a prevalence of 0.6–26%. It is most commonly discovered incidentally as part of the evaluation of LC or in the context of acute decompensation of LC due to portal ...
Savić Željka   +6 more
doaj   +1 more source

LBC-LNBio/KVFinder-web-portal: KVFinder-web portal v1.1.0

open access: yes, 2023
<p>The KVFinder-web portal, developed in R Shiny, delivers the major functionalities of the KVFinder-web service, where users can load a target biomolecule, adjust detection parameters, select run modes, and download and visualize results.
José Geraldo de Carvalho Pereira   +2 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Developing Synthetic Data Tools for Trusted Research Environments to Enable Researcher Training

open access: yesInternational Journal of Population Data Science
We aimed to develop an open-source Python package for the Trusted Research Environment (TRE) community to facilitate the generation of varying levels of synthetic data.
Lewis Hotchkiss   +3 more
doaj   +1 more source

Malformação de Abernethy: uma doença rara

open access: yesResidência Pediátrica, 2022
Abernethy malformation is characterized by an extrahepatic portosystemic shunt. We present the case of a 19-month-old boy with recurrent wheezing and thrombocytopenia under investigation for five months, hospitalized for a hypoxemic respiratory infection.
Maria Maria Mendes   +4 more
doaj   +1 more source

Allocution de Roger Portal (25 juin 1967)

open access: yes, 1967
Portal Roger. Allocution de Roger Portal (25 juin 1967) . In: Annales historiques de la Révolution française, n°189, 1967. pp.
Portal, Roger
core   +1 more source

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