Results 41 to 50 of about 5,466,189 (313)

The structural response of industrial portal frame structures in fire. [PDF]

, 2001
A number of recent fires in single-storey warehouses have drawn attention to a current lack of understanding about the structural response of industrial portal frame structures to elevated temperatures.
Wong, Shao Young, Wong, S.Y.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effect of column base strength on steel portal frames in fire

, 2012
In the UK, the design of steel portal frame buildings in fire is based on the Steel Construction Institute (SCI) design method, in which fire protection needs only be provided to the columns, provided that the column bases are designed to resist an ...
Comlekci, Tugrul, Rahman, Mahbubur, Pritchard, D., Xu, Yixiang, Pritchard, David, Rahman, M., Hamilton, Robert, Lim, James P., Xu, Y., Lim, James B.P., Comlekci, T., Hamilton, R.   +11 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Middle to Late Miocene Trans-Andean Portal: Geologic Record in the Tatacoa Desert

Frontiers in Earth Science, 2021
Integration of several geologic lines of evidence reveals the prevalence of a lowland trans-Andean portal communicating western Amazonia and the westernmost Andes from at least middle Miocene until Pliocene times.
C. Montes, C. A. Silva, G. A. Bayona, R. Villamil, E. Stiles, E. Stiles, A. F. Rodriguez-Corcho, A. Beltran-Triviño, F. Lamus, M. D. Muñoz-Granados, L. C. Pérez-Angel, N. Hoyos, S. Gomez, S. Gomez, J. J. Galeano, E. Romero, E. Romero, M. Baquero, A. L. Cardenas-Rozo, A. von Quadt   +19 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effect of skeletal muscle index on post-embolization syndrome of hepatocellular carcinoma after transarterial chemoembolization

BMC Gastroenterology
Background Skeletal muscle index (SMI) is a commonly used research method for evaluating muscle mass.However, its impact on post-embolization syndrome(PES) of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE ...
Xiaojuan Wang, Jitao Wang, Jinlong Li, Kuopeng Liang, Shoufang Dai, Ruikun Wang, Yi Zhang, Quan Ren, Linglei Meng, Yuzi Qiu   +9 more
doaj   +1 more source

Análisis y rediseño de un portal Web [PDF]

, 2009
El proyecto que a continuación se presenta consiste en analizar y rediseñar el siguiente portal Web “Espacio estudiantes actividad física y deporte”. Este portal es un espacio para los estudiantes de la Universidad Carlos III de Madrid.
Ávila Sánchez, Jessica
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Multidecadal area changes of perennial snowpatches in Yosemite National Park, CA, USA

Arctic, Antarctic, and Alpine Research
Perennial snow and ice features, including both perennial snowpatches and glaciers, play an important role in alpine hydrologic systems, with their melt providing streamflow in years when precipitation and seasonal snowmelt are scarce.
Jackson Hawkins, Rachel Hallnan, Greg M. Stock   +2 more
doaj   +1 more source