Results 91 to 100 of about 27,357 (215)

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development [PDF]

, 2014
Advocacy for better drugs and access to treatment has boosted the interest in drug discovery and development for Chagas disease, a chronic infection caused by the genetically heterogeneous parasite, Trypanosoma cruzi.
Araujo-Junior, Adalberto M., Chatelain, Eric, Franco, Caio H., Freitas-Junior, Lucio H., Giardini, Miriam A., Kim, Hwayoung, Moraes, Carolina B., Schenkman, Sergio   +7 more
core   +1 more source

Case Report: Successful Treatment of Pulmonary Talaromyces marneffei Infection with Posaconazole in a Renal Transplant Recipient.

American Journal of Tropical Medicine and Hygiene, 2020
Talaromyces marneffei (T. marneffei), formerly Penicillium marneffei, is a dimorphic fungus prevalent in Southeast Asia that can cause severe systemic infection, especially in immunocompromised patients.
Qin Lang, A. Chughtai, Weifang Kong, Haiying Yan   +3 more
semanticscholar   +1 more source

Clinical Utility of Frailty Scoring in Elderly Acute Myeloid Leukemia Patients Treated With Venetoclax and Hypomethylating Agents

European Journal of Haematology, Volume 116, Issue 2, Page 160-168, February 2026.
ABSTRACT Acute myeloid leukemia (AML) in elderly patients presents a major therapeutic challenge, as many are deemed unfit for intensive chemotherapy due to age, comorbidities, or frailty. Venetoclax in combination with hypomethylating agents (HMA) has emerged as a standard‐of‐care for this population, yet outcomes remain heterogeneous and predictive ...
Ernesto Vigna, Antonella Bruzzese, Enrica Antonia Martino, Andrea Corsonello, Santino Caserta, Caterina Labanca, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +11 more
wiley   +1 more source

Intravenous and tablet formulation of posaconazole in antifungal therapy and prophylaxis: A retrospective, non-interventional, multicenter analysis of hematological patients treated in tertiary-care hospitals

International Journal of Infectious Diseases, 2019
Objectives: Novel formulations (gastro-resistant tablet and intravenous solution) of posaconazole (POS) have been approved in prophylaxis and therapy of invasive fungal diseases (IFDs).
Sebastian M. Heimann, Olaf Penack, Werner J. Heinz, Tobias Rachow, Gerlinde Egerer, Johanna Kessel, Annika Y. Claßen, Jörg Janne Vehreschild   +7 more
doaj   +1 more source

Current and future chemotherapy for Chagas disease [PDF]

, 2015
Luís Gaspar is thankful to FCT for funding (scholarship reference: SFRH/BD/81604/2011). The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreement No.602773 (Project KINDRED)
Cordeiro-da-Silva, Anabela, Coron, Ross P, Costantino, Luca, Costi, Maria Paola, Ferrari, Stefania, Freitas-Junior, Lucio H, Gaspar, Luís, McKerrow, James H, Moraes, Carolina B, Siqueira-Neto, Jair L, Smith, Terence Kenneth   +10 more
core   +1 more source

Gilteritinib in an Isolated CNS Recurrence of FLT3‐ITD Positive AML

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Time course showing changes in cell count and FLT3‐ITD ratio in cerebrospinal fluid (CSF) from diagnosis through treatment. ABSTRACT Central nervous system (CNS) involvement in adult acute myeloid leukemia (AML) is uncommon and more frequently observed at relapse than at initial presentation.
Lina Susana Silva‐Bermudez, Alexander Streuer, Foteini Christodoulou, Philipp Eisele, Laurenz Steiner, Georgia Metzgeroth, Michael Platten, Wolf‐Karsten Hofmann, Mohammed L. Abba   +8 more
wiley   +1 more source

Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole

PLoS Neglected Tropical Diseases, 2020
Chagas' Disease, caused by the protozoan parasite Trypanosoma cruzi, is responsible for up to 41% of the heart failures in endemic areas in South America and is an emerging infection in regions of North America, Europe, and Asia.
C. M. Calvet, T. A. Silva, Diane Thomas, Brian M. Suzuki, K. Hirata, J. Siqueira-Neto, J. McKerrow   +6 more
semanticscholar   +1 more source

A Report on the Diagnosis and Treatment of Multiple Fungal Critical Brain Abscesses A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Multiple Candida glabrata (C. glabrata) brain abscesses are an exceptionally rare central‐nervous‐system infection. Clinical data on diagnosing and managing multiple Candida glabrata brain abscesses are still scarce. Here we reported a 66‐year‐old patient with multiple C. glabrata brain abscesses confirmed by cerebrospinal‐fluid puncture.
Chongyin Zhang, Dayong Deng, Xiaoning Gao, Lei Yang, Fengzi Yao   +4 more
wiley   +1 more source

Successful treatment of azole-resistant invasive aspergillosis in a bottlenose dolphin with high-dose posaconazole

Medical Mycology Case Reports, 2017
Invasive aspergillosis due to azole-resistant Aspergillus fumigatus is difficult to manage. We describe a case of azole-resistant invasive aspergillosis in a female bottlenose dolphin, who failed to respond to voriconazole and posaconazole therapy.
Paulien E. Bunskoek, Seyedmojtaba Seyedmousavi, Steven J.M. Gans, Peter B.J. van Vierzen, Willem J.G. Melchers, Cornelis E. van Elk, Johan W. Mouton, Paul E. Verweij   +7 more
doaj   +1 more source

Variability in antifungal and antiviral use in hospitalized children [PDF]

, 2017
We analyzed antifungal and antiviral prescribing among high-risk children across freestanding children’s hospitals. Antifungal and antiviral days of therapy varied across hospitals.
Gerber, Jeffrey S, Goldman, Jennifer L, Hersh, Adam L, Kronman, Matthew P, Lee, Brian R, Newland, Jason G, Ross, Rachael K   +6 more
core   +2 more sources