Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Model Predictive Control with a PSO Modelling Approach for Position Control of a Compliant Ankle Rehabilitation Robot. [PDF]
Biomimetics (Basel)Brown DF, Xie SQ, Tu Y.
europepmc +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
A Novel CCS-MPC Algorithm for SPMSM Position Control with Innovative Constraint Processing Strategy. [PDF]
Sensors (Basel)Kong L, Wang J, Dong X, Hu H, Liu B.
europepmc +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Hierarchical Embedded Model Control for Proportional Electro-Hydraulic Valves
, 2015 Hierarchical control architectures are a common approach when hydraulic systems are under study. This paper presents the application of a model-based control structure called Embedded Model Control (EMC) when a hierarchical scheme is implemented on ...
CANUTO, Enrico, Acuna Bravo W
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Adaptive variable impedance hybrid force-position control method for hub-spoke grinding robots. [PDF]
Sci RepWei S +7 more
europepmc +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
A Responsive and Precise Particle Position Control System Combining a Sidewall-Driven Peristaltic Micropump and a High-Speed Camera. [PDF]
Micromachines (Basel)Tanaka Y, Takayama T.
europepmc +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source