Results 61 to 70 of about 14,254,530 (299)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Teacher Education within the Peripherals of Positive Education [PDF]
, 2018 Positive education has a mandate for academic skill development, complemented with approaches that nurture well-being and promote good mental health. It is an added boon in the field of education which aims to churn out a healthy society, procuring
Girdhar, Meenakshi
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Frontiers in PsychologyIntroductionPersonal wellbeing is a multidimensional construct encompassing emotional, psychological, social, and spiritual aspects. To capture this complexity, we introduce the Personal Wellbeing Spectrum Theory, which organizes these dimensions into ...
Attila Oláh +4 more
doaj +1 more source
Studies of the psychological well-being of low-performing students in US schools [PDF]
Современная зарубежная психология, 2019 The article analyzes the psychological well-being of poorly performing schoolchildren and the personal correlates of academic failure as they are presented in the US school psychology.
Lubovsky D.V.
doaj +1 more source
Frameworks for actioning positive and sustainable change in higher education [PDF]
This final chapter draws conclusions from an analysis of knowledge contributions gleaned from previous chapters to develop a consolidated framework for actioning positive and sustainable change in higher education (HE).
Wood, L, Zuber-Skerritt, O
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Application of progressive education in sport [PDF]
, 2007 x, 140 leaves ; 29 cm. --This study exammes tiie possibility of uniting a teaching and coaching perspective of child-centered education through youth sports. The practical nature of sports enables the atiilete to gain knowledge tiirough experience. The
Chisholm, Robin D +1 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source