Results 101 to 110 of about 221,597 (311)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Operators commuting with positive operators [PDF]
Proceedings of the American Mathematical Society, 1979 Necessary and sufficient conditions are obtained for an operator to commute with a positive operator.
openaire +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Kaehler manifolds of positive curvature operator
, 1980 An n-dimensional compact Kaehler manifold of positive curvature operator is real cohomologically equivalent to P n ( C ) {P_n}(C) .
Koichi Ogiue, Shun-ichi Tachibana
core +1 more source
Positive operator valued measures and the quantum Monty Hall problem
Anais da Academia Brasileira de Ciências, 2006 A quantum version of the Monty Hall problem, based upon the Positive Operator Valued Measures (POVM) formalism, is proposed. It is shown that basic normalization and symmetry arguments lead univocally to the associated POVM elements, and that the ...
Claudia Zander +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Results on the number of zero modes of the Weyl-Dirac operator [PDF]
, 2009 For a given magnetic potential A one can define the Weyl-Dirac operator σ·(−i∇−A) on R 3 . An L 2 eigenfunction of σ · (−i∇ − A) corresponding to 0 is called a zero mode.
Ta, Tri, Tạ, Ngọc Trí
core
Positive solutions for fractional differential equation with a p-Laplacian operator
Journal of Hebei University of Science and Technology, 2015 This paper studies the following Caputo fractional differential equation with p-Laplacian of higher-order multi-point: Dβ0+(p(Dα0+u(t)))+f(t,u(t))=0,0≤t≤1,l-1<β≤l,n-1<α≤n,(p(Dα0+u(0)))(i)=0,i=0,1,2,…,l-1,u(i)(0)=0,i=1,2,…,n-1,u(1)=∑ m-
Yunhong LI, Yan LI
doaj +1 more source