Results 111 to 120 of about 17,377,748 (367)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Positive solutions for nonparametric anisotropic singular solutions

open access: yesOpuscula Mathematica
We consider an elliptic equation driven by a nonlinear, nonhomogeneous differential operator with nonstandard growth. The reaction has the combined effects of a singular term and of a "superlinear" perturbation. There is no parameter in the problem. Using variational tools and truncation and comparison techniques, we show the existence of at least two ...
Nikolaos S. Papageorgiou   +2 more
openaire   +2 more sources

Positive solutions of integrodifferential equations [PDF]

open access: yesInternational Journal of Stochastic Analysis, 1992
Integrodifferential equations of the forms urn:x-wiley:20903332:media:ista345783:ista345783-math-0001 are considered, where K ∈ C([0, ∞), [0, ∞)), p ∈ C([0, ∞), [0, ∞)) and q ∈ C((−∞, ∞), [0, ∞)). Necessary conditions and also sufficient conditions for the existence of positive solutions are established.
openaire   +2 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Positive ground state solutions for quasicritical Klein-Gordon-Maxwell type systems with potential vanishing at infinity

open access: yesElectronic Journal of Differential Equations, 2017
This article concerns the Klein-Gordon-Maxwell type system when the nonlinearity has a quasicritical growth at infinity, involving zero mass potential, that is, $V(x)\to 0$, as $|x|\to\infty$.
Elson Leal de Moura   +2 more
doaj  

Positive Solution to Nonzero Boundary Values Problem for a Coupled System of Nonlinear Fractional Differential Equations

open access: yes, 2010
We consider the existence and uniqueness of positive solution to nonzero boundary values problem for a coupled system of fractional differential equations. The differential operator is taken in the standard Riemann-Liouville sense.
Jinhua Wang, Hongjun Xiang, Zhigang Liu
semanticscholar   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

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