Results 121 to 130 of about 5,619,071 (301)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

An elliptic problem with arbitrarily small positive solutions

open access: yesElectronic Journal of Differential Equations, 2000
We show that for each $lambda > 0$, the problem $-Delta_p u = lambda f(u)$ in $Omega$, $u = 0$ on $partial Omega$ has a sequence of positive solutions $(u_n)_n$ with $max_{Omega} u_n$ decreasing to zero.
Pierpaolo Omari, Fabio Zanolin
doaj  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Existence of positive solutions for superlinear p-Laplacian equations

open access: yesElectronic Journal of Differential Equations, 2015
We obtain a positive solution for a superlinear p-Laplacian equations with the Dirichlet boundary-value conditions. Our main tool is a variation of the mountain pass theorem.
Ting-Mei Gao, Chun-Lei Tang
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Positive solutions for elliptic equations with singular nonlinearity

open access: yesElectronic Journal of Differential Equations, 2005
We study an elliptic boundary-value problem with singular nonlinearity via the method of monotone iteration scheme: $$displaylines{ -Delta u(x)=f(x,u(x)),quad x in Omega,cr u(x)=phi(x),quad x in partial Omega , }$$ where $Delta$ is the Laplacian ...
Junping Shi, Miaoxin Yao
doaj  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Positive solutions of boundary-value problems for 2m-order differential equations

open access: yesElectronic Journal of Differential Equations, 2003
This article concerns the existence of positive solutions to the differential equation $$ (-1)^m x^{(2m)}(t)=f(t,x(t),x'(t),dots,x^{(m)}(t)), quad ...
Yuji Liu, Weigao Ge
doaj  

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