Results 151 to 160 of about 17,377,748 (367)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Positive solutions for second-order singular three-point boundary-value problems with sign-changing nonlinearities

Electronic Journal of Differential Equations, 2010
In this article, we study the existence and uniqueness of the positive solution for a second-order singular three-point boundary-value problem with sign-changing nonlinearities. Our main tool is a fixed-point theorem.
Caisheng Ji, Baoqiang Yan
doaj  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Three positive solutions for m-point boundary-value problems with one-dimensional p-Laplacian

Electronic Journal of Differential Equations, 2011
In this article, we study the multipoint boundary value problem for the one-dimensional p-Laplacian $$ (phi_p(u'))'+ q(t)f(t,u(t),u'(t))=0,quad tin (0,1), $$ subject to the boundary conditions $$ u(0)=sum_{i=1}^{m-2} a_iu(xi_i),quad u'(1)=eta u'(0)
Donglong Bai, Hanying Feng
doaj  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Existence of positive solutions for nonlinear systems of second-order differential equations with integral boundary conditions on an infinite interval in Banach spaces

Electronic Journal of Differential Equations, 2011
The article shows the existence of positive solutions for systems of nonlinear singular differential equations with integral boundary conditions on an infinite interval in Banach spaces.
Xu Chen, Xingqiu Zhang
doaj  

A Solution of Indoor Positioning System

Proceedings of the 2013 International Conference on Advanced Computer Science and Electronics Information, 2013
This paper describes the use of ultra broadband indoor location technology within the area of the unified all personnel and equipment in planning, scheduling solution, realize the full view of the systematic monitoring sites, coherent continuous tracking and track the extraction.
openaire   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Uniqueness of positive solutions for an elliptic system arising in a diffusive predator-prey model

Electronic Journal of Differential Equations, 2013
In this note, we study the uniqueness of positive solutions for an elliptic system which arises in a diffusive predator-prey model in the strong-predator case. The main result extends an earlier results by the same authors.
Xiaodan Wei, Wenshu Zhou
doaj