Results 151 to 160 of about 5,619,071 (301)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
On the Existence of Positive Decaying Entire Solutions for a Class of Sublinear Elliptic Equations [PDF]
, 1988 Yasuhiro Furusho, Takaŝi Kusano
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Existence of multiple solutions for quasilinear elliptic equations in R^N
Electronic Journal of Differential Equations, 2014 In this article, we establish the multiplicity of positive weak solution for the quasilinear elliptic equation $$\displaylines{ -\Delta_p u+\lambda|u|^{p-2}u=f(x) |u|^{s-2 }u+h(x)|u|^{r-2}u\quad x\in \mathbb{R}^N,\cr u>0\quad x\in \mathbb{R}^N ...
Honghui Yin, Zuodong Yang
doaj
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Electronic Journal of Differential Equations, 2006 We consider multiplicity of positive solutions for second-order m-point boundary-value problems, with the first order derivative involved in the nonlinear term. Using a fixed point theorem, we show the existence of at least three positive solutions.
Liu Yang, Xiping Liu, Chunfang Shen
doaj
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Existence of positive solutions to three-point phi-Laplacian BVPs via homotopic deformations
Electronic Journal of Differential Equations, 2012 Under suitable conditions and via homotopic deformation, we provide existence results for a positive solution to the three-point $phi$-Laplacian boundary-value problem $$displaylines{ -( aphi(u'))'(x)=b(x) f(x,u(x)),quad xin ( 0,1), cr u(0)=alpha u ...
Nadir Benkaci +2 more
doaj
Positive solutions of nonlinear elliptic equations—existence and nonexistence of solutions with radial symmetry in 𝐿_{𝑝}(𝑅^{𝑁}) [PDF]
, 1984 John Toland
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