Results 151 to 160 of about 13,731,074 (335)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Positive solutions for elliptic equations with singular nonlinearity

open access: yesElectronic Journal of Differential Equations, 2005
We study an elliptic boundary-value problem with singular nonlinearity via the method of monotone iteration scheme: $$displaylines{ -Delta u(x)=f(x,u(x)),quad x in Omega,cr u(x)=phi(x),quad x in partial Omega , }$$ where $Delta$ is the Laplacian ...
Junping Shi, Miaoxin Yao
doaj  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Positive solutions of boundary-value problems for 2m-order differential equations

open access: yesElectronic Journal of Differential Equations, 2003
This article concerns the existence of positive solutions to the differential equation $$ (-1)^m x^{(2m)}(t)=f(t,x(t),x'(t),dots,x^{(m)}(t)), quad ...
Yuji Liu, Weigao Ge
doaj  

Positive solutions of a class of linear systems

open access: yesLinear Algebra and its Applications, 1985
This delightful paper consists of a useful sufficient condition in order that the solution of a linear algebraic system have positive components and explains how this result applies directly to ecological models. For the matrices A, \(m\times m\), B, \(m\times n-m\), C, n-m\(\times m\), D, n-m\(\times n-m\), x, \(m\times 1\), y, n-m\(\times 1\), f, \(m\
openaire   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

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