Results 81 to 90 of about 456,539 (203)

Solvability of nonlinear integral equations of product type

Electronic Journal of Differential Equations, 2018
This article concerns nonlinear functional integral equations of product type. The first two equations set on a the positive half-axis encompass different classes of nonlinear integral equations and may involve the product of finitely many integral ...
Bilal Boulfoul, Azzeddine Bellour, Smail Djebali   +2 more
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Path-integral quantization of Galilean Fermi fields

, 2015
The Galilei-covariant fermionic field theories are quantized by using the path-integral method and five-dimensional Lorentz-like covariant expressions of non-relativistic field equations.
Abreu, Abrikosov, Banks, Bazeia, Crawford, Crawford, Das, de Montigny, de Montigny, de Montigny, de Montigny, de Montigny, del Olmo, Duval, Duval, Duval, Duval, Duval, Duval, F.C. Khanna, F.M. Saradzhev, Fetter, Greiner, Hassaïne, Hassaïne, Horvathy, Horvathy, Horvathy, Horzela, Horzela, Jackiw, Jackiw, Jackiw, Jackiw, Jackiw, Kapuścik, Kapuścik, Kapuścik, Kogut, Kogut, Künzle, Le Bellac, Lifshitz, Lukierski, Lévy-Leblond, Lévy-Leblond, M. de Montigny, Nambu, Nambu, Omote, Peskin, Pinski, Santos, Santos, Soper, Susskind, Takahashi, Takahashi, Tsvelik, Weinberg, Weinberg, Zwiebach   +61 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A gapless charge mode induced by the boundary states in the half-filled Hubbard open-chain

, 1998
We discuss the ground state and some excited states of the half-filled Hubbard model defined on an open chain with L sites, where only one of the boundary sites has a different value of chemical potential.
Asakawa H, Bedürftig G, Deguchi T, Imada M, Imada M, Koichi Kusakabe, Ruihong Yue, Schulz H, Shiroishi M, Takhtajan L A, Tetsuo Deguchi, Tsuchiya O, Woynarovich F, Woynarovich F, Yue R H   +14 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Iterative solution of integral equations on a basis of positive energy Sturmian functions [PDF]

Physical Review E, 2012
18 figures, 2 ...
openaire   +3 more sources