Results 101 to 110 of about 3,156,256 (308)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
How Does Household Income Affect Child Personality Traits and Behaviors? [PDF]
, 2015 Existing research has investigated the effect of early childhood educational interventions on the child's later-life outcomes. These studies have found limited impact of supplementary programs on children's cognitive skills, but sustained effects on ...
E. Costello +3 more
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Anosmia and Ageusia as the Only Indicators of Coronavirus Disease 2019 (COVID-19) [PDF]
, 2020 The patient is a 60-year-old woman with a history of vertigo and seasonal allergies who presented to the hospital with the chief complaint of headache. Radiological findings were negative for intracranial abnormalities. The headache was due to trigeminal
Abdollahi, Shahrzad +3 more
core +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Stop Turning a Blind Eye: Tobacco Smoking Among Egyptian Patients With Schizophrenia
Frontiers in Psychiatry, 2019 Background: Patients with schizophrenia have considerably higher rates of mortality than general population. Multiple factors may play a role in this.
Hussien Elkholy +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Journal of Holistic Nursing and Midwifery, 2019 Introduction: Although humor plays an important role in improving people s mental and physical health, empirical studies on the effectiveness of humor skills training to improve the symptoms of the patients with schizophrenia are scarce.
Akbar Atadokht +2 more
doaj
Perception of burden by caregivers of patients with schizophrenia in relation to symptom profile
Annals of Indian Psychiatry, 2019 Background: Schizophrenia begins early in life causing significant long-lasting impairments. The caregivers face physical, psychological, and economic difficulties in taking care of them.
Bharathi Gunjahalli, P M Chougule
doaj +1 more source