Results 111 to 120 of about 1,944,556 (307)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Beyond dopamine: functional MRI predictors of responsiveness to cognitive behaviour therapy for psychosis [PDF]

, 2010
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Johns, LC, Dominic Fannon, Kuipers, Elizabeth; id_orcid, Dominic H Ffytche, Peters, Emmanuelle R; id_orcid, McGuire, PA, Kumari, V, Preethi Premkumar, Antonova, E, Elizabeth Kuipers, Williams, SRC, McGuire, Philip A, Williams, SCR, Philip A McGuire, Raveendran, Vinodkumar, Elena Antonova, Premkumar, P, McGuire, PK, Louise C Johns, Kuipers, E, Johns, Louise C, Peters, ER, Ffytche, DH, Veena Kumari, Raveendran, V, Fannon, D, Andrew, Christopher, Steven C R Williams, Kumari, Veena, Ffytche, Dominic H, Emmanuelle R Peters, Antonova, Elena; id_orcid, Vinodkumar Raveendran, Christopher Andrew, Williams, Steven C.R.; id_orcid, Andrew, C, Fannon, Dominic, Premkumar, Preethi   +37 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Selective deficits in semantic verbal fluency in patients with a first affective episode with psychotic symptoms and a positive history of mania [PDF]

, 2009
Objectives:  Neurocognitive dysfunction is likely to represent a trait characteristic of bipolar disorder, but the extent to which it comprises ‘core’ deficits as opposed to those secondary to longstanding illness or intellectual decline is unclear.
Kravariti, Eugenia; id_orcid, Zanelli, J., Fearon, Paul, Doody, G.A., Jones, Peter B., Reichenberg, A., Lappin, J.M., Morgan, Kevin, Murray, Robin M., Morgan, K.D., Harrison, Glynn, Morgan, Craig, Jones, P.B., Zanelli, Jolanta W., Morgan, C., Doody, Gillian A., Reichenberg, Abraham, Dazzan, Paola; id_orcid, Murray, R.M., Fearon, P., Dazzan, P., Lappin, Julia M., Harrison, G., Kravariti, E.   +23 more
core   +1 more source

The impact of mobile health interventions on patients with schizophrenia: a meta-analysis

Frontiers in Psychiatry
ObjectiveTo systematically evaluate the impact of mobile health (mHealth) interventions on patients with schizophrenia.MethodsRandomized controlled trials (RCTs) concerning the effects of mHealth interventions on patients with schizophrenia were ...
Yongli Ye, Fangrui Zhang, Yangyang Zhou
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source