Results 191 to 200 of about 156,433 (260)

TSH Ligand‐Based CAR‐T Cell Effectively Eradicates TSHR‐Positive Thyroid Cancer with Favorable Safety Profile

Advanced Science, EarlyView.
TSHR is highly expressed in differentiated thyroid cancer (DTC), making it an ideal target for adoptive immune cell therapy. A novel Ligand‐based TSH‐CAR‐T cell approach effectively eradicated TSHR‐positive thyroid tumors in vitro and accomplished full remission in tumor models with favorable safety profile, highlighting that TSH‐CAR‐T cells could ...
Fei Wang, Hui Zuo, Li Liu, Shiyuan Wang, Haifang Zhao, Zhao Liu, Gang Wang, Zhao Liu, Junnian Zheng, Chuan Xu, Hongwei Du   +10 more
wiley   +1 more source

Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1+/Itga11+ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury

Advanced Science, EarlyView.
This study demonstrates that a hydrogel with mechanical properties matching the spinal cord directs fibroblast alignment, reshaping fibrotic scars into parallel matrices. A specific fibroblast subset mediates extracellular matrix remodeling through mechanotransduction, promoting axonal regeneration and neural reconnections, revealing potential ...
Longyou Xiao, Kaixi Shi, Wen Li, Jialin Liu, Pengfei Xie, Zijun Hu, Yu Dai, Haiyan Weng, Qiuju Yuan, Wutian Wu, Limin Rong, Liumin He   +11 more
wiley   +1 more source

[Cross-Lagged Analysis of Sleep Duration and Positive Youth Development in Primary and Secondary School Students]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban
Zhang Z, Chen D, Li Z, Mei S, Xiong Z, Fan Z, Shen J, Zhao L.   +7 more
europepmc   +1 more source

Phenylboronic Acid‐Modified Copper Nanozymes as Nanoscavengers of Bacterial Polysaccharides Causing Acute Lung Injury

Advanced Science, EarlyView.
A novel copper nanocluster coated with 4‐mercaptobenzeneboronic acid (CuMPBA) is developed to target bacterial polysaccharides for addressing complicated acute lung injury (ALI) caused by severe burns and early pulmonary infections. CuMPBA exhibits dual anti‐inflammatory and antibacterial mechanisms by: (a) binding and degrading toxic bacterial ...
Haojie Ge, Min Wang, Haijiao Xie, Xu‐Lin Chen, Xianwen Wang   +4 more
wiley   +1 more source

Bimetal‐Phenolic Framework to Combat Bacterial Infections via Synergistic Biofilm Dispersal, Bacterial Killing and Immune Modulation

Advanced Science, EarlyView.
A bimetal‐phenolic framework (Que‐Fe‐CeMPF) is developed by direct self‐assembly through the coordination of Fe3+ and Ce4+ with quercetin. Que‐Fe‐CeMPF exhibits multimodal activity, including cleaving matrix eDNA within biofilm, generating hydroxyl radicals via catalytic H2O2 to kill bacteria, and alleviating inflammation by stimulating macrophage ...
Yaran Wang, Fan Wu, Lei Hua, Chang Gao, Siran Wang, Yong Liu, Yijin Ren, Linqi Shi, Henny C. van der Mei, Yuanfeng Li   +9 more
wiley   +1 more source

Antioxidant Carbon Dot of Selenomethionine Alleviates Oxidative Stress in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A selenomethionine‐derived carbon dot (Se‐Met‐CD) serves as a potent nano‐antioxidant, efficiently scavenging reactive oxygen species, protecting nucleus pulposus cells from oxidative damage, restoring extracellular matrix homeostasis, and significantly mitigating intervertebral disc degeneration in vivo, which demonstrates great promise as a nanozyme ...
Qingzheng Zhang, Zongtai Liu, Yirong Sun, Changfeng Fu, Jianxun Ding   +4 more
wiley   +1 more source

Probing the Dynamics Process of High‐Entropy Alloy Catalysts: Fundamentals, Synthesis, and In Situ TEM Insights

Advanced Science, EarlyView.
Schematic illustration of the basic properties, machine learning synthesis strategy, and formation under in situ TEM of HEAs. Abstract Catalysts play a crucial role in advancing green and clean energy technologies for a sustainable future. Among the various catalysts reported, high‐entropy alloys (HEAs) stand out due to their superior stability and ...
Haider Ali, Yan Xu, Xiao Han, Yue Lin
wiley   +1 more source

Multiferroicity in Calcium Manganate via Strain Engineering

Advanced Electronic Materials, EarlyView.
Multiferroicity is achieved in the non‐ferroelectric magnet calcium manganate through tensile‐strain engineering. The ferroelectricity below 45 K is evidenced by the polarization‐electric field hysteresis loops, and the magnetization below 125 K is confirmed by the magnetization measurements.
Ye Yuan, Zhen Yang, Cheng Ma, Kui‐juan Jin, Shuai Xu, Er‐jia Guo, Chen Ge, Can Wang, Xiulai Xu, Meng He, Guozhen Yang   +10 more
wiley   +1 more source

Nonequilibrium Nitrogen Spike Annealing for Crystallization Enhancement Achieves High Mobility and Reliability in IGO TFTs

Advanced Electronic Materials, EarlyView.
Nitrogen‐Spike Annealing (NSA) enables crystallization of In‐Ga‐O semiconductors, reducing defect states. Compared with the conventional annealing method, NSA induces a preferentially oriented phase, enabling poly‐IGO TFTs with ≈86 cm2 V s−1 mobility and enhanced reliability, breaking the mobility‐reliability trade‐off.
Kuo Zhang, Jiayi Wang, Ziheng Bai, Chunyu Zhang, Tong Yu, Yang Xu, Nannan You, Rui Chen, Zhicheng Wu, Di Geng, Guanhua Yang, Shengkai Wang, Ling Li, Ming Liu   +13 more
wiley   +1 more source

King and Cochrane: The technological treadmill and racial inequity in US agriculture

Applied Economic Perspectives and Policy, EarlyView.
Abstract Between 1920 and 1969, the number of Black farmers in the US decreased from 14% of all operators to 4%. Using Martin Luther King Jr.'s critique of agricultural policy and Willard Cochrane's theory of the technological treadmill, we explore how racial discrimination was linked to policies that led to structural change in US agriculture.
Jared Hutchins, Jacopo De Marinis
wiley   +1 more source