Results 81 to 90 of about 15,388 (303)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

On the completely positive and positive-semidefinite-preserving cones

Linear Algebra and its Applications, 1984
Let \(M_ n\), \(H_ n\), and \(P_ n\) be respectively the complex space of \(n\times n\) complex matrices, the real space of Hermitian matrices in \(M_ n\), and the cone of positive semidefinite matrices in \(H_ n\). The authors show that the cone \(CP_{n,q}\) of completely positive linear maps from \(M_ n\) to \(M_ q\) is isometrically isomorphic to ...
Barker, George Phillip, Hill, Richard D., Haertel, Raymond D.   +2 more
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Finite element approximation of a nonlinear cross-diffusion population model [PDF]

, 2003
We consider a fully discrete finite element approximation of the nonlinear cross-diffusion population model: Find u i, the population of the ith species, i = 1 and 2, such that ∂ui ∂t −Δ [ ci ui + ai u2i + ui uj] − bi ∇.
John W. Barrett, Blowey, J.F., James F. Blowey, Blowey, JF, Barrett, J.W., John W. Barrett, Barrett, JW   +6 more
core   +1 more source

A Well-Balanced Wet–Dry Front Reconstruction for Two-Layer Shallow Water Flows

Mathematics
In this paper, a well-balanced and positivity-preserving scheme for the nonconservative two-layer shallow water equations is developed in the framework of the finite volume method. To address the challenges posed by wet–dry fronts, the focus of our study
Xue Wang
doaj   +1 more source

A novel time efficient structure-preserving splitting method for the solution of two-dimensional reaction-diffusion systems

Advances in Difference Equations, 2020
In this article, the first part is concerned with the important questions related to the existence and uniqueness of solutions for nonlinear reaction-diffusion systems.
Nauman Ahmed, Alper Korkmaz, M. Rafiq, Dumitru Baleanu, Ali Saleh Alshomrani, M. A. Rehman, M. S. Iqbal   +6 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A novel holographic framework preserving reflection positivity in dSd spacetime

Physics Letters B
This manuscript introduces a novel holographic correspondence in d-dimensional de Sitter (dSd) spacetime, connecting bulk dSd scalar unitary irreducible representations (UIRs) with their counterparts at the dSd boundary I±, all while preserving ...
Jean-Pierre Gazeau, Mariano A. del Olmo, Hamed Pejhan   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source