Results 91 to 100 of about 7,957,612 (305)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

On the completely positive and positive-semidefinite-preserving cones

Linear Algebra and its Applications, 1984
Let \(M_ n\), \(H_ n\), and \(P_ n\) be respectively the complex space of \(n\times n\) complex matrices, the real space of Hermitian matrices in \(M_ n\), and the cone of positive semidefinite matrices in \(H_ n\). The authors show that the cone \(CP_{n,q}\) of completely positive linear maps from \(M_ n\) to \(M_ q\) is isometrically isomorphic to ...
Barker, George Phillip, Hill, Richard D., Haertel, Raymond D.   +2 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A novel holographic framework preserving reflection positivity in dSd spacetime

Physics Letters B
This manuscript introduces a novel holographic correspondence in d-dimensional de Sitter (dSd) spacetime, connecting bulk dSd scalar unitary irreducible representations (UIRs) with their counterparts at the dSd boundary I±, all while preserving ...
Jean-Pierre Gazeau, Mariano A. del Olmo, Hamed Pejhan   +2 more
doaj   +1 more source

A novel time efficient structure-preserving splitting method for the solution of two-dimensional reaction-diffusion systems

Advances in Difference Equations, 2020
In this article, the first part is concerned with the important questions related to the existence and uniqueness of solutions for nonlinear reaction-diffusion systems.
Nauman Ahmed, Alper Korkmaz, M. Rafiq, Dumitru Baleanu, Ali Saleh Alshomrani, M. A. Rehman, M. S. Iqbal   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Well-Balanced Wet–Dry Front Reconstruction for Two-Layer Shallow Water Flows

Mathematics
In this paper, a well-balanced and positivity-preserving scheme for the nonconservative two-layer shallow water equations is developed in the framework of the finite volume method. To address the challenges posed by wet–dry fronts, the focus of our study
Xue Wang
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source