Results 91 to 100 of about 15,388 (303)

A positivity preserving and oscillation-free entropy stable discontinuous Galerkin scheme for the reactive Euler equations [PDF]

The reactive Euler equations are a basic model for fluid flows with chemical reactions. In this work, we construct a high order positivity preserving and oscillation-free entropy stable discontinuous Galerkin (DG) scheme for the reactive Euler equations.
Zhao, Weifeng, Lin, Ping, Zuo, Hujian
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Positivity preserving operator splitting nonstandard finite difference methods for SEIR reaction diffusion model

Open Mathematics, 2019
In this work, we will introduce two novel positivity preserving operator splitting nonstandard finite difference (NSFD) schemes for the numerical solution of SEIR reaction diffusion epidemic model.
Ahmed Nauman, S.S. Tahira, Rafiq M., Rehman M.A., Ali Mubasher, Ahmad M.O.   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Positive explicit and implicit computational techniques for reaction–diffusion epidemic model of dengue disease dynamics

Advances in Difference Equations, 2020
The aim of this work is to develop a novel explicit unconditionally positivity preserving finite difference (FD) scheme and an implicit positive FD scheme for the numerical solution of dengue epidemic reaction–diffusion model with incubation period of ...
Nauman Ahmed, Muhammad Rafiq, Dumitru Baleanu, Ali Saleh Alshomrani, Muhammad Aziz-ur Rehman   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

High order positivity-preserving finite volume WENO schemes for a hierarchical size-structured population model

, 2011
In this paper we develop high order positivity-preserving finite volume weighted essentially non-oscillatory (WENO) schemes for solving a hierarchical size-structured population model with nonlinear growth, mortality and reproduction rates.
Shu, Chi-Wang, Rui Zhang, Mengping Zhang, Zhang, Rui, Chi-Wang Shu, Zhang, Mengping   +5 more
core   +1 more source

Issues with Positivity-Preserving Patankar-type Schemes

, 2022
Patankar-type schemes are linearly implicit time integration methods designed to be unconditionally positivity-preserving. However, there are only little results on their stability or robustness.
Philipp Öffner, Torlo, D., Davide Torlo, Torlo, Davide, Hendrik Ranocha, Ranocha, Hendrik, Offner, P., Öffner, Philipp, Ranocha, H.   +8 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source