Results 101 to 110 of about 15,388 (303)

Unconditional positivity-preserving and energy stable schemes for a reduced poisson-nernst-planck system

, 2020
The Poisson-Nernst-Planck (PNP) system is a widely accepted model for simulation of ionic channels. In this paper, we design, analyze, and numerically validate a second order unconditional positivity-preserving scheme for solving a reduced PNP system ...
Maimaitiyiming, Wumaier, Liu, Hailiang
core   +1 more source

Ingham type approach for uniform observability inequality of the semi-discrete coupled wave equations

Electronic Journal of Differential Equations, 2020
This article concerns an observability inequality for a system of coupled wave equations for the continuous models as well as for the space semi-discrete finite difference approximations.
Dilberto da Silva Almeida Junior, Anderson de Jesus Araujo Ramos, Joao Carlos Pantoja Fortes, Mauro de Lima Santos   +3 more
doaj  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Numerical Solution of the Sine–Gordon Equation by Novel Physics-Informed Neural Networks and Two Different Finite Difference Methods

Axioms
This study employs a novel physics-informed neural network (PINN) approach, the standard explicit finite difference method (EFDM) and unconditionally positivity preserving FDM to tackle the one-dimensional Sine–Gordon equation (SGE).
Svetislav Savović, Miloš Ivanović, Branko Drljača, Ana Simović   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A general positivity-preserving algorithm for implicit high-order finite volume schemes solving the Euler and Navier-Stokes equations

, 2023
This paper presents a general positivity-preserving algorithm for implicit high-order finite volume schemes solving Euler and Navier-Stokes equations.
Ren, Yu-Xin, Wang, Qian, Huang, Qian-Min
core  

A family of positive nonstandard numerical methods with application to Black-Scholes equation [PDF]

Sahand Communications in Mathematical Analysis, 2017
Nonstandard finite difference schemes for the Black-Scholes partial differential equation preserving the positivity property are proposed. Computationally simple schemes are derived by using a nonlocal approximation in the reaction term of the Black ...
Mohammad Mehdizadeh Khalsaraei, Nashmil Osmani   +1 more
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Numerical Testing of a New Positivity-Preserving Interpolation Algorithm

, 2022
An important component of a number of computational modeling algorithms is an interpolation method that preserves the positivity of the function being interpolated. This report describes the numerical testing of a new positivity-preserving algorithm that
Kirby, Robert M., Berzins, Martin, Ouermi, T. A. J.   +2 more
core  

An Inexact Noda Iteration for Computing the Smallest Eigenpair of a Large, Irreducible Monotone Matrix

Mathematics
In this paper, we introduce an inexact Noda iteration method featuring inner and outer iterations for computing the smallest eigenvalue and corresponding eigenvector of an irreducible monotone matrix.
Ching-Sung Liu
doaj   +1 more source