Results 101 to 110 of about 7,957,612 (305)

Positivity preserving operator splitting nonstandard finite difference methods for SEIR reaction diffusion model

Open Mathematics, 2019
In this work, we will introduce two novel positivity preserving operator splitting nonstandard finite difference (NSFD) schemes for the numerical solution of SEIR reaction diffusion epidemic model.
Ahmed Nauman, S.S. Tahira, Rafiq M., Rehman M.A., Ali Mubasher, Ahmad M.O.   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Positive explicit and implicit computational techniques for reaction–diffusion epidemic model of dengue disease dynamics

Advances in Difference Equations, 2020
The aim of this work is to develop a novel explicit unconditionally positivity preserving finite difference (FD) scheme and an implicit positive FD scheme for the numerical solution of dengue epidemic reaction–diffusion model with incubation period of ...
Nauman Ahmed, Muhammad Rafiq, Dumitru Baleanu, Ali Saleh Alshomrani, Muhammad Aziz-ur Rehman   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ingham type approach for uniform observability inequality of the semi-discrete coupled wave equations

Electronic Journal of Differential Equations, 2020
This article concerns an observability inequality for a system of coupled wave equations for the continuous models as well as for the space semi-discrete finite difference approximations.
Dilberto da Silva Almeida Junior, Anderson de Jesus Araujo Ramos, Joao Carlos Pantoja Fortes, Mauro de Lima Santos   +3 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Numerical Solution of the Sine–Gordon Equation by Novel Physics-Informed Neural Networks and Two Different Finite Difference Methods

Axioms
This study employs a novel physics-informed neural network (PINN) approach, the standard explicit finite difference method (EFDM) and unconditionally positivity preserving FDM to tackle the one-dimensional Sine–Gordon equation (SGE).
Svetislav Savović, Miloš Ivanović, Branko Drljača, Ana Simović   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source