Results 71 to 80 of about 216,080 (283)

Optical Nanoscopy for Elucidating Nano–Bio Interactions: A One Health Perspective

Advanced Optical Materials, EarlyView.
The review comprehensively summarizes the application of far‐field fluorescence nanoscopy for the characterization of nanomaterial interactions with biological systems at the single‐particle and molecular scale, with an accent on their impact on human and ecosystem health.
Elisa De Luca, Chiara Coricciati, Marcella Trombetta, Giuseppe Gigli, Pamela Mozetic, Alberto Rainer   +5 more
wiley   +1 more source

Imaging of the calcium activated potassium channel 3.1 (KCa3.1) in vivo using a senicapoc‐derived positron emission tomography tracer

Archiv der Pharmazie, Volume 355, Issue 12, December 2022., 2022
The 18F‐labeled derivative [18F]3 of senicapoc was synthesized using the prosthetic group approach with 1‐azido‐2‐[18F]fluoroethane ([18F]6) in a “click” reaction. The biological activity of the new positron emission tomography tracer was evaluated in vitro and in vivo.
Christian P. Konken, Kathrin Heßling, Insa Thale, Sonja Schelhaas, Jennifer Dabel, Sarah Maskri, Etmar Bulk, Thomas Budde, Oliver Koch, Albrecht Schwab, Michael Schäfers, Bernhard Wünsch   +11 more
wiley   +1 more source

Nuclear neurotransmitter molecular imaging of autism spectrum disorder

AIMS Molecular Science, 2019
Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by marked deficits in social communication and interaction, including limited and repetitive patterns of behavior.
Alveena Batool Syed, James Robert Brašić   +1 more
doaj   +1 more source

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

Advanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan   +12 more
wiley   +1 more source

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Advanced Science, EarlyView.
This study presents the NEV β‐secretase activity assay, a groundbreaking method for noninvasive evaluation of β‐secretase activity in Alzheimer's disease (AD) patients, enabling the generation of individualized β‐secretase activity profiles.
Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng   +19 more
wiley   +1 more source

Prognostic value of subventricular zone involvement in relation to tumor volumes defined by fused MRI and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET imaging in glioblastoma multiforme

Radiation Oncology, 2019
Background Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time- and cost-effective ...
Maciej Harat, Bogdan Małkowski, Krzysztof Roszkowski   +2 more
doaj   +1 more source

A Novel Theranostic Strategy for Malignant Pulmonary Nodules by Targeted CECAM6 with 89Zr/131I‐Labeled Tinurilimab

Advanced Science, EarlyView.
This study investigates the integrated diagnostic and therapeutic strategy utilizing 89Zr/131I‐labeled tinurilimab for the management of malignant lung nodules, with a particular focus on lung adenocarcinoma (LUAD). CEACAM6, which is highly expressed in most LUAD patients, activates the Src/FAK signaling pathway, thereby promoting cell proliferation ...
Chongyang Chen, Keying Zhu, Jing Wang, Donghui Pan, Xinyu Wang, Yuping Xu, Junjie Yan, Lizhen Wang, Min Yang   +8 more
wiley   +1 more source

Combining PSA and PET features to select candidates for salvage lymph node dissection in recurrent prostate cancer

BJUI Compass, Volume 4, Issue 1, Page 123-129, January 2023., 2023
Abstract Objective To evaluate the relationship between pre‐operative PSA value, 68Ga‐prostate‐specific‐membrane‐antigen (PSMA) PET performance and oncologic outcomes after salvage lymph node dissection (sLND) for biochemical recurrent prostate cancer (PCa).
Carlo A. Bravi, Axel Heidenreich, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Armando Stabile, Vito Cucchiara, Daniar Osmonov, Klaus‐Peter Juenemann, R. Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Bernhard Grubmüller, Shahrokh Shariat, Derya Tilki, Markus Graefen, Inderbir S. Gill, Alexander Mottrie, Pierre I. Karakiewicz, Francesco Montorsi, Alberto Briganti, David Pfister   +28 more
wiley   +1 more source

Randomized control trial of using tongue acupuncture in autism spectrum disorder

Journal of Traditional Chinese Medical Sciences, 2014
Objective: The therapeutic approach of traditional chinese Medicine (TCM) in autism spectrum disorder (ASD) is a functional one. To study the efficacy, safety and functional brain change from the use of tongue acupuncture (TAC) on ASD children.
Virginia Chun-Nei Wong, Jie-Guang Sun, David Wai-Chow Yeung   +2 more
doaj   +1 more source

Distinct CTC Specific RNA Profile Enables NSCLC Early Detection and Dynamic Monitoring of Advanced NSCLC

Advanced Science, EarlyView.
A quantitative CTC RNA assay is developed by incorporating multi‐antibody‐based CTC isolation and specific mRNA quantification using RT‐ddPCR. The NSCLC CTC ScoreD demonstrates high accuracy for early‐stage NSCLC detection, significantly outperforming serum CEA. NSCLC CTC ScoreM exhibits a more accurate early‐warning of responses to different therapies
Xiaoyu Wang, Pi Ding, Wenjuan Xu, Lei Qiu, Jing Ren, Yucheng Fei, Zhili Wang, Cheng Li, Yufei Xing, Mingjing Shen, Yawen Zhu, Yun Guo, Na Sun, Renjun Pei, Minhua Shi   +14 more
wiley   +1 more source