Results 81 to 90 of about 1,853,110 (305)

Deep learning based bilateral filtering for edge-preserving denoising of respiratory-gated PET

EJNMMI Physics
Background Residual image noise is substantial in positron emission tomography (PET) and one of the factors limiting lesion detection, quantification, and overall image quality. Thus, improving noise reduction remains of considerable interest.
Jens Maus, Pavel Nikulin, Frank Hofheinz, Jan Petr, Anja Braune, Jörg Kotzerke, Jörg van den Hoff   +6 more
doaj   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Alzheimer's Disease Biomarkers Measured by Capillary Blood Collection Versus Venous Plasma and Cerebrospinal Fluid

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Blood biomarkers are increasingly critical for non‐invasive Alzheimer's Disease (AD) diagnostics and research but typically require on‐site processing. Remote point‐of‐care collection methods could enhance biomarker testing in clinical and research settings.
Sara Ho, Ziling Shen, Alexandria Lewis, Megha Patel, Anny Zheng, Gianna Proscino, Thaovy Ho, Jiangxia Wang, Marilyn Albert, Abhay Moghekar   +9 more
wiley   +1 more source

Stage‐Specific Patterns of Imaging and Non‐Motor Biomarkers in Spinocerebellar Ataxia Type 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Advancements in disease‐modifying therapies for spinocerebellar ataxia Type 3 (SCA3) underscore the need for robust biomarkers to monitor disease progression and evaluate treatment efficacy. Although motor phenotypes have been well characterized, less is known about non‐motor and imaging‐based features across different disease stages.
Chun Li, Zhi‐Xian Ye, Xuan‐Yu Chen, Liang‐Liang Qiu, Zhi‐li Chen, Yu‐Sen Qiu, Wei Lin, Ru‐Ying Yuan, Xin‐Tong Yu, Chun‐Yu Huang, Xin‐Yuan Chen, Min‐Ting Lin, Jian‐Ping Hu, Wan‐Jin Chen, Ning Wang, Shao‐Bo Yao, Shi‐Rui Gan, Ying Fu   +17 more
wiley   +1 more source

Radiosynthesis of [¹⁸F]-Labelled Pro-Nucleotides (ProTides)

Molecules, 2020
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success.
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell   +7 more
doaj   +1 more source

A Two‐Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p‐Tau217 Gray Zone

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐Tau217 leaves 30%–50% of patients in an indeterminate “gray zone” often requiring Aβ‐PET. We developed GRAD (Gatekeeper‐Reflex for Alzheimer's Disease), a two‐stage Aβ‐positivity prediction model to improve classification while reserving Aβ‐PET for residual uncertainty.
Harthik Parankusham, Casey Vanderlip, Colin Birkenbihl, Eashwar Krishna, Chizobam Ugboaja, Andrew E. Budson, Brandon Frank, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
wiley   +1 more source

Role of Ultrasound-Guided Fine Needle Aspiration in Assessing the Impalpable Cervical Node with Increased 18f-Fluorodeoxyglucose Uptake on Positron Emission Tomography Scanning: Preliminary Communication

, 2011
OBJECTIVES: 18F-Fluorodeoxyglucose positron emission tomography can detect cervical metastases before they are palpable. However, false positive results are not uncommon. This paper reports the use of ultrasound-guided fine needle aspiration to determine
王成平;李仲毅;婁培人;顏若芳;蕭仲凱;柯政郁, WANG, CHENG-PING;LEE, CHUNG-YI;LOU, PEI-JEN;YEN, RUOH-FANG;HSIAO, JONG-KAI;KO, JENQ-YUH   +1 more
core   +1 more source

Quantifying lung growth with CT-derived intrapulmonary vascular volume: a cross-sectional study

BMC Medical Imaging
Background This study aimed to evaluate lung growth by the quantitative assessment of intrapulmonary vascular volume on chest CT images. Methods All 1122 subjects were grouped with a 2-year age span.
Meijuan Shi, Peng Gao, Meng Li, Weili Yang, Nan Yin, Youmin Guo, Cong Shen   +6 more
doaj   +1 more source

Associations Between Biomarkers of Alzheimer's Disease and Sleep in Cognitively Unimpaired Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sleep disturbances have been implicated as a risk factor for developing Alzheimer's disease (AD), but evidence linking plasma AD biomarkers to sleep in cognitively unimpaired individuals remains limited. The present study examined associations between evening, morning, and overnight changes in plasma AD biomarkers and measures of ...
Cornelia Sauter, Hans Dorn, Julian Hellmann‐Regen, Ana Bueno‐Lopez, Verena van Ginneken, Heidi Danker‐Hopfe   +5 more
wiley   +1 more source

Review of Positron Emission Tomography at Royal Prince Alfred Hospital, CHERE Project Report No 18 [PDF]

This report is a review of the clinical uses, impacts on clinical management, clinical outcome and resource use of Positron Emission Tomography (PET) at Royal Prince Alfred Hospital (RPAH).Positron emission ...
Christine Pollicino, Rosalie viney, Anastasia Lowin, Phil Haywood, Michael Fulham   +4 more
core