Results 81 to 90 of about 1,081,743 (292)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Personality Separation Anxiety Problem in the Method «I-Reconstruction»

open access: yesВісник Харківського національного університету імені В.Н. Каразіна. Серія: Психологія
The article deals with the adult separation anxiety problem through the psychotherapy method "I-reconstruction". A definition of the separation anxiety concept is given as well as it highlights the process of the anxiety occurrence in psychological ...
Yuliia Zinchenko
doaj   +1 more source

Une histoire sociolinguistique de la possession d’Aix-en-Provence (1610-1611)

open access: yesEtudes Epistémè, 2017
In an important case of possession from early 17th-century France (also called the affair of Gaufridy or of Madeleine de Demandols), the devils are extremely loquacious. The figure of the preaching devil is preeminent.
Jean-Pierre Cavaillé, Sophie Houdard
doaj   +1 more source

Supply-side reduction policy and drug-related harm [PDF]

open access: yes
Large-scale seizures of cocaine, heroin and amphetamine-type substances (ATS) do not result in any reduction in overdoses on these drugs or on arrests for use and possession of these drugs, according to this report.
Don Weatherburn   +4 more
core   +1 more source

A new species of Phyllophaga Harris from the island of Navassa in the Caribbean (Coleoptera: Scarabaeidae: Melolonthinae) [PDF]

open access: yes, 2011
The small Caribbean island of Navassa (U.S. possession) is unoccupied by humans, but recent surveys have detected a surprising number of endemic (precinctive) invertebrates. A new species of May beetle, Phyllophaga navassa, is here described and compared
Steiner, Warren E., Woodruff, Robert E.
core  

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Situer la possession. Du droit romain de l’appartenance aux nouveaux modèles propriétaires

open access: yesClio@Themis, 2018
This article calls for a reengagement with historical forms of legal appropriation. Exploring ways to benefit from a ressource that ran parallel to exclusive property, it aims at providing legal scholars with an archeological touchstone capable of ...
Pierre Thévenin
doaj   +1 more source

One Million Police Hours: Making 440,000 Marijuana Possession Arrests in New York City [PDF]

open access: yes, 2013
A new report released today documents the astonishing number of hours the New York Police Department has spent arresting and processing hundreds of thousands of people for low-level misdemeanor marijuana possession arrests during Mayor Bloomberg's tenure.
Gabriel Sayegh   +2 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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