Results 121 to 130 of about 3,919,087 (316)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
On The Possibility of Price Decreasing Bubbles [PDF]
It is often argued that a rational bubble, because it is positive, must increase the price of a stock. This argument is not valid in general: as soon as bubbles affect interest rates, the fundamental value of a stock depends on whether or not a bubble is
Philippe Weil
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Transcendental and Normative Critique: Convergence or Opposition?
Філософія освітиThe article analyzes the phenomenon of transcendental critique in relation to normative critique. The author, initially distinguishing between transcendental and normative critical discourses as distinct and, in certain respects, oppositional ...
Анна Ільїна
doaj +1 more source
Spaces of Possibility In, Between, and Beyond Korea and Japan
Cover -- Contents -- Acknowledgments -- List of Illustrations -- Foreword -- Introduction: Movement, Collaboration, Spaces of Difference -- PART I: SPACES OF THE COLONIAL PRESENT -- 1 The Remains of Colonial History -- 2 When Is a Prison like a Folk Art ...
Sorensen, Clark W. +1 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
J. David Velleman (2000) The Possibility of Practical Reason
, 2004 Perceptie, cognitie ...
Verbeek, B.J.E.
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
EMBODIED SCIENCE: RECENTERING RELIGION‐AND‐SCIENCE
Zygon, 2010 Neither religion nor science is first of all a realm of pure ideas, even though religion‐and‐science discussions often assume that they are. I propose that a concept of embodied science is more adequate and that religion‐and‐science should center its ...
doaj +2 more sources