Results 121 to 130 of about 9,087,077 (299)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Transcendental and Normative Critique: Convergence or Opposition?
Філософія освітиThe article analyzes the phenomenon of transcendental critique in relation to normative critique. The author, initially distinguishing between transcendental and normative critical discourses as distinct and, in certain respects, oppositional ...
Анна Ільїна
doaj +1 more source
Possibility of tanbeta measurement in CMS at LHC
, 2005 The achievable tanbeta determination accuracy for CMS at LHC is presented. Using MSSM H/A->tau tau decay in the associated production process gg->bbH/A the event rates are measured at large tanbeta and the systematic and statistical errors are estimated.
Hashemi, Majid
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
EMBODIED SCIENCE: RECENTERING RELIGION‐AND‐SCIENCE
Zygon, 2010 Neither religion nor science is first of all a realm of pure ideas, even though religion‐and‐science discussions often assume that they are. I propose that a concept of embodied science is more adequate and that religion‐and‐science should center its ...
doaj +2 more sources