Results 81 to 90 of about 3,919,087 (316)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Rola negacji w opisie świata według arystotelesowskiej Metafizyki [PDF]
Argument, 2012 The notions of „being” and „non-being” have entered philosophical language, forming thebasis of ontology and meontology, as the counterparts of the Greek expressions to o]n and tomh o]n (nominalised forms, affirmative and negative, of the participle of ...
Jan BIGAJ
doaj
Comparing Fuzzy Sets and Random Sets to Model the Uncertainty of Fuzzy Shorelines
Remote Sensing, 2017 This paper addresses uncertainty modelling of shorelines by comparing fuzzy sets and random sets. Both methods quantify extensional uncertainty of shorelines extracted from remote sensing images. Two datasets were tested: pan-sharpened Pleiades with four
Ratna Sari Dewi +2 more
doaj +1 more source
Possibility and permissibility [PDF]
We generalize permissibility (Brandenburger, 1992) to allow for any suitably defined model of preference and definition of possibility. We also prove that the generalized solution concept characterizes rationality, caution, and “common belief" of ...
Kin Chung Lo
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Possibility functions and regular economies [PDF]
In the spirit of Smale's work, we consider pure exchange economies with general consumption sets. In this paper, the consumption set of each household is described in terms of a function called possibility function.
Jean-Marc Bonnisseau +1 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Sententiae, 2016 The article deals with the problem of phenomenological interpretation of Cartesian idea of evidence. The author demonstrates that implicit but constitutive characteristic of evidence is a property of excessiveness. The analysis of its conceptual versions
Anna Ilyina
doaj +1 more source