Results 151 to 160 of about 36,908 (274)

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

British Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer, Daniel Finke, Sebastian Romann, Norbert Frey, Joerg Heineke, Lorenz H. Lehmann   +5 more
wiley   +1 more source

The insulin‐like growth factor system and the progression of renal complications of type 2 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims Chronic kidney disease is associated with dysregulation of the insulin‐like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF‐I, IGF‐II, IGFBPs and progression of kidney ...
Adrian Heald, Yasitha lllangasekera, Andreas Matheou, Ram Prakash Narayanan, Stephen White, Hellena Habte‐Asres, Abigail Lay, Liliana Shalamanova, William Ollier, Graham A. Hitman, Ritwika Mallik, Philip A. Kalra, Martin Whyte, J. Martin Gibson   +13 more
wiley   +1 more source

The burden of diabetic foot ulcers in a multi‐ethnic Asian cohort

Diabetic Medicine, EarlyView.
Abstract Aims Diabetic foot ulcers (DFUs) are a major source of morbidity among individuals with diabetes mellitus (DM), imposing a substantial burden on healthcare systems. Our institution established a multidisciplinary service aiming to facilitate early specialist intervention for DFU management.
Zongwen Wee, Yong Mong Bee, Sueziani Binte Zainudin   +2 more
wiley   +1 more source

ACE inhibitors as a therapy for sarcopenia — Evidence and possible mechanisms

The Journal of nutrition, health and aging, 2008
Sumukadas, D., Witham, M. D., Struthers, A. D., McMurdo, M. E. T.   +3 more
openaire   +3 more sources

Tirzepatide for Obesity in Adults ≥ 65 Years: A Post Hoc Analysis of the SURMOUNT and SUMMIT Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Tirzepatide is a once‐weekly glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonist (RA) approved for weight management in adults with obesity. Data on older adults remain limited, however. This study aimed to examine tirzepatide's safety and efficacy in adults aged ≥ 65 years with obesity ...
Nasreen Alfaris, Robert F. Kushner, Jianghao Li, Kevin L. Chen, Mia Fenimore, Boris Calderon, Adam Stefanski   +6 more
wiley   +1 more source

Classifying Possible Sarcopenia With a Single Inertial Sensor During Gait

Physical Therapy Korea
Background: Sarcopenia is a progressive age-related musculoskeletal disorder. Early identification is critical for effective intervention. However, current criteria are time-consuming and require various equipment, limiting their utility.
Junwoo Park, Kitaek Lim, Seyoung Lee, Jongwon Choi, Donggeon Kim, Sungmin Chun, Soyeon Yoon, Woochol Joseph Choi   +7 more
doaj   +1 more source

Effects of Incretin‐Based Therapies, Diet and Exercise Interventions, and Bariatric Surgery on Fat‐Free Mass in Adults With Overweight or Obesity: A Systematic Review and Meta‐Analysis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Maintaining fat‐free mass (FFM) during weight loss is important to maintain a healthy body composition. This review examined changes in FFM during weight loss induced by diet and exercise interventions, incretin‐based therapies, and bariatric surgery, and assessed whether the relative loss of FFM differs by weight‐loss modality ...
Laura Busk‐Cirera, Ida Ørum Carlsen, Lærke Bruun Madsen, Rasmus Michael Sandsdal, Emma Jensen, Simon Birk Kjær Jensen, Signe Sørensen Torekov   +6 more
wiley   +1 more source

Genetic and Environmental Effects on BMI Fluctuation Across the Adult Life Course and Its Associations With Baseline BMI and BMI Change: An Individual‐Based Study of 14 Longitudinal Twin Cohorts

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Body mass index (BMI) fluctuation has adverse health consequences, yet its determinants remain poorly understood. We examined genetic and environmental influences on BMI fluctuation and its associations with BMI trajectories. Data and Methods Data from 14 longitudinal twin cohorts, including 58 311 individuals (54% women) and 22 ...
Alvaro Obeso Fernandez, Anders Eriksson, Gabin Drouard, Aline Jelenkovic, Sari Aaltonen, Miina Ollikainen, Timothy Spector, Massimo Mangino, Kaare Christensen, Axel Skytthe, Kirsten O. Kyvik, Emanuela Medda, Corrado Fagnani, Robin P. Corley, Brooke M. Huibregtse, Virgilia Toccaceli, Finn E. Rasmussen, Per Tynelius, Sarah E. Medland, Scott D. Gordon, Glen E. Duncan, Dedra Buchwald, Patrik K. E. Magnusson, Ida K. Karlsson, Anna K. Dahl Aslan, Meike Bartels, Lannie Ligthart, Eco J. C. de Geus, Margaret Gatz, David A. Butler, Hyojin Pyun, Jeeeun Kim, Soo Ji Lee, Joohon Sung, Susanne Bruins, René Pool, Nicholas G. Martin, Dorret I. Boomsma, Jaakko Kaprio, Karri Silventoinen   +39 more
wiley   +1 more source

GLP‐1‐Based Therapies in Type 1 Diabetes: Emerging Evidence on Cardiovascular, Renal, and Safety Outcomes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Individuals living with type 1 diabetes (T1D) are at increased risk for cardiovascular (CV) and renal complications, yet therapeutic strategies specifically targeting cardiorenal risk reduction in this population remain limited. The role of glucagon‐like peptide‐1 (GLP‐1)‐based therapies in T1D remains unclear.
Anastasios Tentolouris, Djordje S. Popovic, Alexandros L. Liarakos, Alexandros Briasoulis, Nikolaos Papanas, Theocharis Koufakis   +5 more
wiley   +1 more source

Leisure‐Time Physical Activity on Age‐Modelled Trajectories of Body Mass Index and Obesity Risk Throughout Life: Multivariable Regression and Mendelian Randomization Analyses Using Electronic Health Record Data From the CORDELIA‐Catalunya Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess whether self‐reported leisure‐time physical activity, moderate‐to‐vigorous leisure‐time physical activity, and genetically determined cardiorespiratory fitness are associated with age‐related BMI trajectories and incident obesity. Methods We pooled 14 993 adults (30–90 years; 52.7% women; cohorts: REGICOR‐ACRISC, ILERVAS, ARTPER)
Javier Hernando‐Redondo, Anna Camps‐Vilaró, Roberto Elosua, Eleonora Fornara, Marcelino Bermúdez‐López, Pere Torán‐Monserrat, Ainara Jiménez‐Navarro, José M. Valdivielso, Víctor M. López‐Lifante, Tomàs Salas‐Fernández, Serafí Cambray, Raquel Cruz, Jaume Marrugat, Álvaro Hernáez   +13 more
wiley   +1 more source