Results 61 to 70 of about 7,597,013 (263)
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Errors of clinical diagnostics laboratory and their management [PDF]
, 2010 Aim of the study: Evaluate clinical diagnostics laboratory errors and their management possibilities. Study methodology: Laboratory X error registry study performed (2007 – 2009 year).
Keliuotienė, Rasma
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
ERRORS IN CLINICAL LABORATORY RESEARCH: THEIR NATURE, CAUSES, AND THERAPEUTIC IMPLICATIONS
Diagnostic errors, such as missing, delayed, or inaccurate diagnoses, are a common type of medical error and preventable iatrogenic harm. Mistakes committed during the laboratory testing process can lead to diagnostic errors. Examining the ...
Madaminova, Zamira
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
A Program Based on Special Processes Approach and its Effectiveness on Treating Arabic Language Errors for Non-Arabic Translators [PDF]
مجلة بحوث التعليم والإبتكارThis study investigated the effectiveness of a program based on the Arabic for Specific Purposes (ASP) approach in remediating linguistic errors among non-native Arabic speakers.
Mohamed Sayed Haggag +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Errors in the total testing process in the clinical chemistry laboratory at the University of Gondar Hospital, northwest Ethiopia [PDF]
, 2018 Background: Laboratory services have been described as the major processes contributing to safe patient care in the modern healthcare sector. However, occurrences of errors in the overall testing processes impair the clinical decision-making process ...
Worede, Abebaw +17 more
core +1 more source