Results 51 to 60 of about 1,840 (204)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Reconsidering Acting: a few improvised and provisory thoughts on acting today
Revista Brasileira de Estudos da Presença, 2015 This paper summarizes my thoughts during the presentation of the conference Acting reconsidered. The study of the actor in contemporary performances should be reevaluated in the light of the experiments of the last fifty years, particularly performance ...
Patrice Pavis (University of Kent, Canterbury – United Kingdom)
doaj
The Concepts of Time, Memory and Identity in Beckett’s Essay on Proust
ABEI Journal, 2005 Beckett’s essay on Proust, in which he examines the philosophical concepts of time, memory and identity, has exerted enormous influence on modernist and post-modernist writers, who have consciously adapted and re- synthesized the ideas he developed not ...
Anna Stegh Camati
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Reconsidering Acting: a few improvised and provisory thoughts on acting today
Revista Brasileira de Estudos da Presença, 2016 This paper summarizes my thoughts during the presentation of the conference Acting reconsidered. The study of the actor in contemporary performances should be reevaluated in the light of the experiments of the last fifty years, particularly performance ...
Patrice Pavis
doaj
Il re si diverte e muore: un itinerario dal grottesco all’assurdo
Itinera, 2013 This essay first discusses Victor Hugo’s defence of grotesque, his defence of Shakespeare, his achievements in Le roi s’amuse, and also the limitations due to his prophetic style.
Paulo Filipe Monteiro
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
A Kuka de Kamaiorá ou O Segredo da Alma D'ouro: metaficção historiográfica, 1973-1983
Aletria: Revista de Estudos de Literatura, 1995 This essay analyses Leilah Assunção's post-modern play, a Kuka de Kamaiorá, which was written in 1973 but only staged ten years later. A careful reading of the dramatic text reveals some ideological confrontation among different sociopolitical strata in ...
Júnia de Castro Magalhães Alves
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source