Results 41 to 50 of about 271,434 (255)

Addressing Social Issues Using Humors in Mayat (1978) Dramatic Text by Hatta Azad Khan

Responsible Education, Learning and Teaching in Emerging Economies, 2022
Objective: In the dramatic world, humour has been part of releasing tension for readers. Hatta Azad Khan is a renowned Malaysian dramatist who always addresses social issues in his writings.
Abdul Walid Ali, Saad Omar, Muhammad Faisal Bin Ahmad   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Performing the Theatricality in the Game of Framings: rethinking the weaving of the dramatic

Revista Brasileira de Estudos da Presença, 2016
Through the analysis of contemporary propositions and postulating the game of framings as the principle of scene poetics building, this article analyzes the notions of theatricality and performativity as co-existing functions.
Rejane Arruda (Universidade Vila Velha ‒ UVV, Vila Velha/ES, Brazil)
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Performing the Theatricality in the Game of Framings: rethinking the weaving of the dramatic

Revista Brasileira de Estudos da Presença, 2017
Through the analysis of contemporary propositions and postulating the game of framings as the principle of scene poetics building, this article analyzes the notions of theatricality and performativity as co-existing functions. Displaced from the field of
Rejane Arruda
doaj  

The theatrical praxis and its visual roots: Sarah Kane, Maurice Maeterlinck and the Post-Dramatic

Urdimento: Revista de Estudos em Artes Cênicas, 2023
This article discusses probable visual roots for theatrical praxis. I observed derivations originating in the Greek verb théa, as well as in the noun theatron, found in ancient Greece. Starting from this context, I identified theoretical links with Hans-Thies Lehmann, Peter Szondi and Ewald Hackler.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

William Szekspir w postpamięciowym dyskursie o zagładzie

Politeja, 2015
The aim of the paper is to discuss the role of literary output of William Shakespeare in post‑memorial discourse about Holocaust. It analyzes various culture texts (film and theater adaptations, memoirs, essays and short stories) devoted to Holocaust ...
Agata Dąbrowska
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source