Results 31 to 40 of about 129,890 (245)

Pilot study on medical translations in lay language : post-editing by language specialists, domain specialists or both? [PDF]

, 2019
Despite the rich history of research into medical translation, there is a notable lack of empirical studies on the best workflow for this task, especially in a modern translation setting involving post-editing of machine translation. This pilot study was
Buysschaert, Joost, Lefever, Els, Macken, Lieve, Rigouts Terryn, Ayla, Vander Stichele, Robert, Vanneste, Koen   +5 more
core   +1 more source

Translation methods and experience : a comparative analysis of human translation and post-editing with students and professional translators [PDF]

, 2017
While the benefits of using post-editing for technical texts have been more or less acknowledged, it remains unclear whether post-editing is a viable alternative to human translation for more general text types.
Daems, Joke, Hartsuiker, Robert, Macken, Lieve, Vandepitte, Sonia   +3 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Variant analysis pipeline for accurate detection of genomic variants from transcriptome sequencing data.

PLoS ONE, 2019
The wealth of information deliverable from transcriptome sequencing (RNA-seq) is significant, however current applications for variant detection still remain a challenge due to the complexity of the transcriptome.
Modupeore O Adetunji, Susan J Lamont, Behnam Abasht, Carl J Schmidt   +3 more
doaj   +1 more source

TERMS: Techniques for electronic resources management [PDF]

, 2013
Librarians and information specialists have been finding ways to manage electronic resources for over a decade now. However, much of this work has been an ad hoc and learn-as-you-go process.
Emery, Jill, Stone, Graham
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands

BMC Genomics, 2020
Background The development and application of CRISPR technologies for the modification of the genome are rapidly expanding. Advances in the field describe new CRISPR components that are strategically engineered to improve the precision and reliability of
M. Heath Farris, Pamela A. Texter, Agustin A. Mora, Michael V. Wiles, Ellen F. Mac Garrigle, Sybil A. Klaus, Kristine Rosfjord   +6 more
doaj   +1 more source

The impact of using text-to-speech (TTS) in post-editing machine translation (PEMT) workflows on translators’ cognitive effort, productivity, quality, and perceptions

Tradumàtica tecnologies de la traducció
This eye-tracking experiment investigates the impact of text-to-speech (TTS) alongside translation and post-editing machine translation (PEMT) experience on translators’ cognitive effort, productivity, quality, and perceptions during PEMT from English into German.
Ciobanu, Dragos, Rios, Miguel, Secară, Alina, Brockmann, Justus, Chereji, Raluca-Maria, Wiesinger, Claudia   +5 more
openaire   +2 more sources