Results 41 to 50 of about 79,486 (217)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Development and Application of Digital Surgery Video Cloud-Based Management Platform

Zhongguo yiliao qixie zazhi
In response to bottlenecks such as multi-source data integration and large-volume video data processing in traditional operating rooms, this paper proposes and develops a cloud-based digital surgical video management platform.
Zheng GU, Yonghua CHU, Cancan XU, Ye XU, Zhenjie LIU   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Taboo, Wordplay, and Intertextuality: Evaluating Human and AI Performance in Translating English Humour into Polish Subtitles

Dialogica
Humour in animated audiovisual dialogue is strongly context-dependent and difficult to subtitle because translators must reproduce a comparable comic effect under constraints of time, space, segmentation, reading speed, and synchrony.
Olga Pióro
doaj   +1 more source

Detection of CRISPR-mediated genome modifications through altered methylation patterns of CpG islands

BMC Genomics, 2020
Background The development and application of CRISPR technologies for the modification of the genome are rapidly expanding. Advances in the field describe new CRISPR components that are strategically engineered to improve the precision and reliability of
M. Heath Farris, Pamela A. Texter, Agustin A. Mora, Michael V. Wiles, Ellen F. Mac Garrigle, Sybil A. Klaus, Kristine Rosfjord   +6 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The Impact of Training on Electronic Health Records Related Knowledge, Practical Competencies, and Staff Satisfaction: A Pre-Post Intervention Study Among Wellness Center Providers in a Primary Health-Care Facility

Journal of Multidisciplinary Healthcare, 2023
Sarah Musa,1 Ismail Dergaa,1 Rawia Al Shekh Yasin,2 Rajvir Singh3 1Department of Preventative Health, Primary Health Care Corporation (PHCC), Doha, Qatar; 2Department of Quality & Patient Safety, Primary Health Care Corporation (PHCC), Doha, Qatar ...
Musa S, Dergaa I, Al Shekh Yasin R, Singh R   +3 more
doaj  

Machine translation in a professional translation workflow: post-editing or computer aided translation

, 2023
La localización es un campo fascinante que ha cambiado drásticamente en los últimos años y todavía está cambiando y adaptándose a medida que la sociedad lo hace. El uso de la traducción automática ha desarrollado este campo de manera asombrosa. Muchas empresas han comenzado a incluir la traducción automática en sus flujos de trabajo para cumplir con ...
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source