Results 21 to 30 of about 79,486 (217)

Establishment of a CRISPR/Cas9-Based Genome Editing System in Macrobrachium rosenbergii

Animals
The giant freshwater prawn Macrobrachium rosenbergii is a globally farmed decapod species of high economic and nutritional value, but its genetic improvement has been constrained by the lack of an efficient genome editing workflow.
Junjun Yan, Siyu Qian, Guo Li, Yujie Liu, Liqian Zhou, Tiantian Ye, Cui Liu, Jilun Meng, Yukun Jie, Zhimin Gu   +9 more
doaj   +1 more source

Mass Spectrometry in Allogeneic CAR-T Cell Manufacturing: From Cellular Starting Materials to Multi-Attribute Quality Control

Cells
Chimeric antigen receptor (CAR) T-cell therapies have demonstrated remarkable clinical efficacy in hematological malignancies, yet their broader application is constrained by manufacturing complexity and variability, particularly in autologous settings ...
Naryeong Kim, Zhouyang Huang, Michael Born, Julien Camperi   +3 more
doaj   +1 more source

Implementation of deep learning-based auto-segmentation for radiotherapy planning structures: a workflow study at two cancer centers

Radiation Oncology, 2021
Purpose We recently described the validation of deep learning-based auto-segmented contour (DC) models for organs at risk (OAR) and clinical target volumes (CTV).
Jordan Wong, Vicky Huang, Derek Wells, Joshua Giambattista, Jonathan Giambattista, Carter Kolbeck, Karl Otto, Elantholi P. Saibishkumar, Abraham Alexander   +8 more
doaj   +1 more source

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

AI Era Classroom Beyond Post-Editing: Custom Gpts in Translator Training

Вісник Харківського національного університету імені В. Н. Каразіна. Серія Іноземна філологія. Методика викладання іноземних мов
The article addresses the current pedagogical dissonance in translator training, where Large Language Models (LLMs) are either banned or students are confined to the remedial task of post-editing of LLM output, neglecting the critical up- and downstream ...
Viacheslav Karaban, Anna Karaban
doaj   +1 more source

Introducing Quality Estimation to Machine Translation Post-editing Workflow: An Empirical Study on Its Usefulness

CoRR
This preliminary study investigates the usefulness of sentence-level Quality Estimation (QE) in English-Chinese Machine Translation Post-Editing (MTPE), focusing on its impact on post-editing speed and student translators' perceptions. It also explores the interaction effects between QE and MT quality, as well as between QE and translation expertise ...
Siqi Liu, Guangrong Dai, Dechao Li
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Accelerating Workflows in Video Game Translation: A Recommender System for Review and Post-Edit Assignments

ACM Transactions on Recommender Systems
The advancement in Neural Machine Translation (NMT) has significantly improved the localisation of content across multiple languages, offering fluency and efficiency. However, in complex applications, such as the translation of video games, where there is a need to preserve original player experiences, NMT alone cannot capture subtleties such as humour.
Mukande, Tendai, Dinkov, Dimiter, Superbo, Riccardo, O'Connor, Noel E.   +3 more
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source