Utility of Machine Learning in the Prediction of Post-Hepatectomy Liver Failure in Liver Cancer [PDF]
Journal of Hepatocellular CarcinomaPosthepatectomy liver failure (PHLF) is a serious complication associated with high mortality rates. Machine learning (ML) has rapidly developed and may outperform traditional models in predicting PHLF in patients who have undergone hepatectomy. This study aimed to predict PHLF using ML and compare its performance with that of traditional scoring ...
Tashiro,Hirotaka +10 more
openaire +5 more sources
Predictors of Post-Hepatectomy Liver Failure in Klatskin Tumors: The Role of Preoperative Glucose, Future Liver Remnant to Spleen Ratio, and Early Bilirubin Monitoring [PDF]
DiagnosticsBackground: Post-hepatectomy liver failure (PHLF) is a serious complication following hepatic resection for Klatskin tumors, significantly affecting patient prognosis.
Suyeon Kim +14 more
doaj +2 more sources
HMGB1-Mediated Cell Death—A Crucial Element in Post-Hepatectomy Liver Failure [PDF]
International Journal of Molecular SciencesLiver resection (LR) is the primary treatment for hepatic tumors, yet posthepatectomy liver failure (PHLF) remains a significant concern. While the precise etiology of PHLF remains elusive, dysregulated inflammatory processes are pivotal. Therefore, we explored the theragnostic potential of extracellular high-mobility-group-box protein 1 (HMGB1), a key
Laura Brunnthaler +12 more
openaire +3 more sources
Development and Validation of Prediction Models and Risk Calculators for Post-Hepatectomy Liver Failure and Postoperative Complications using a Diverse International Cohort of Major Hepatectomies [PDF]
, 2023 Objective: The study aim was to develop and validate models to predict clinically significant post-hepatectomy liver failure (PHLF) and serious complications (a Comprehensive Complication Index® [CCI®]>40) using preoperative and intraoperative variables.
Benedetti Cacciaguerra, Andrea +15 more
core +1 more source
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
Liver Transplantation in Patients with Post-Hepatectomy Liver Failure – A Northern European Multicenter Cohort Study [PDF]
HPB, 2022 Liver transplantation (LTX) has been described as a rescue treatment option in severe, intractable post-hepatectomy liver failure (PHLF), but is not considered to be indicated for this condition by many hepatobiliary and transplant surgeons. In this article we describe the clinical experience of five northern European tertiary centers in using LTX to ...
Sparrelid, Ernesto +13 more
openaire +5 more sources
Preoperative Predictive Nomogram Based on Alanine Aminotransferase, Prothrombin Time Activity, and Remnant Liver Proportion (APART Score) to Predict Post-Hepatectomy Liver Failure after Major Hepatectomy [PDF]
, 2023 Introduction: Post-hepatectomy liver failure (PHLF) is a serious complication associated with major hepatectomies. An accurate prediction of PHLF is necessary to determine the feasibility of major hepatectomy.
IIDA, Hiroya +8 more
core +2 more sources
Journal of Minimal Access Surgery, 2021 Mini-invasive approaches in hepatic surgery are associated with a significant decrease in the incidence of post-operative morbidity and liver failure. Intraoperative blood loss represents the major intraoperative accident during hepatectomy. Infrahepatic
Francesco Marchegiani +3 more
doaj +1 more source
The role of serial lactate and liver enzyme dynamics in predicting post hepatectomy liver failure [PDF]
, 2023 Background: Post-hepatectomy liver failure (PHLF) is an important cause of morbidity and mortality following liver resection. Current prognostic models only allow for the detection of PHLF on post-operative day 5.
Soldati, Vuyolwethu Sonwabile
core +1 more source
Frontiers in Oncology, 2022 PurposeThe impact of sarcopenia on the future liver remnant (FLR) growth after portal vein occlusion, including portal vein embolization (PVE) and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has gained increasing ...
Qiang Wang +7 more
doaj +1 more source