Results 141 to 150 of about 55,914 (233)

Model‐Informed Evaluation of Hydroxyurea Exposure During Lactation

Clinical Pharmacology &Therapeutics, EarlyView.
Hydroxyurea is a cornerstone therapy for sickle cell anemia; however, evidence guiding its use during lactation remains limited. This study aimed to develop a population pharmacokinetic (PK) model to characterize hydroxyurea disposition in maternal plasma and breast milk, and to quantify infant exposure under clinically relevant breastfeeding scenarios.
Anhar Hosawi, Kei Irie, Min Dong, Julie Ware, Russell Ware, Tomoyuki Mizuno   +5 more
wiley   +1 more source

Interventions for Visual Field Loss After Acquired Brain Injury: A Systematic Review. [PDF]

Life (Basel)
Díaz-Marín N, López-de-la-Fuente C, Marcén Y, Pérez-Rey J, Bilbao C, López-de-la-Fuente MJ.   +5 more
europepmc   +1 more source

The in‐hospital administration of sacubitril/valsartan in acute myocardial infarction: A meta‐analysis

ESC Heart Failure, Volume 12, Issue 2, Page 998-1012, April 2025.
In patients with Acute Myocardial Infarction related heart failure, the in‐hospital administration of ARNIs was associated with a reduced risk of MACEs and re‐hospitalizations for heart failure, as well as cardiac remodeling, compared to standard therapy.
Gianluca Di Pietro, Riccardo Improta, Paolo Severino, Andrea D'Amato, Lucia Ilaria Birtolo, Ovidio De Filippo, Antonio Lattanzio, Raffaele De Cristofaro, Giacchino Galardo, Fabrizio D'Ascenzo, Roberto Badagliacca, Gennaro Sardella, Maurizio Volterrani, Francesco Fedele, Carmine Dario Vizza, Massimo Mancone   +15 more
wiley   +1 more source

Application of photobiomodulation in post-stroke dysfunctions: a literature review of recent clinical studies. [PDF]

Front Neurol
Ren C, Chi X, Jiang Y.
europepmc   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Vision-language models for human motion understanding: Lessons from stroke rehabilitation. [PDF]

PLOS Digit Health
Li V, Kamalakannan N, Parnandi A, Schambra H, Fernandez-Granda C.   +4 more
europepmc   +1 more source

Pathological hippocampal–cortical hypersynchronization disrupts memory in temporal lobe epilepsy: A multimodal intracranial electroencephalographic–functional magnetic resonance imaging study

Epilepsia, EarlyView.
Abstract Objective Memory impairment is a common comorbidity in temporal lobe epilepsy (TLE) and is thought to arise from hippocampal dysfunction and disrupted interactions within a distributed memory network involving medial temporal, frontal, and parietal cortical regions.
Ruxue Gong, Xiaolong Peng, Rebecca W. Roth, Haris Rashid, William Yun, Daniel L. Drane, Leonardo Bonilha, Lisa McTeague, Ezequiel Gleichgerrcht   +8 more
wiley   +1 more source

Early treatment prevents neuronal loss in experimental status epilepticus: A magnetic resonance spectroscopic imaging study

Epilepsia, EarlyView.
Abstract Objective In status epilepticus there are concerns that the prolonged high‐intensity electrographic seizure activity causes neuronal death and poorer outcomes. In animal models of status epilepticus, early treatment that stops the seizures prevents the later development of epilepsy.
Yue Chen, Erik J. Fernandez, Edward H. Bertram   +2 more
wiley   +1 more source

Diagnostics and rehabilitation of post-stroke visual field loss using innovative visual field evaluation. The impact of losing driving privileges (DRIVE-study): Protocol for a randomized controlled trial. [PDF]

Contemp Clin Trials Commun
Rosenvinge MF, Lundmark PO, Larsen SE, Eilertsen G, Falkenberg HK.   +4 more
europepmc   +1 more source

Functional profiling of STXBP1 missense variants using a novel dual‐readout fluorometric assay

Epilepsia, EarlyView.
Abstract Objective STXBP1‐related disorders (STXBP1‐RD) are among the most common genetic neurodevelopmental disorders, marked by early onset epilepsy, global developmental delay, and motor impairments. Many missense variants remain uncharacterized, limiting accurate variant interpretation and hindering development of precision therapies.
Elisa A. Waxman, Jennine M. Dawicki‐McKenna, Ian McSalley, Anna J. Prentice, Torrey A. Chisari, Sarah M. Ruggiero, Jillian L. McKee, Alex J. Felix, Giulia Pavani, Benjamin L. Prosser, Michael J. Boland, Ingo Helbig   +11 more
wiley   +1 more source