Results 151 to 160 of about 694,082 (344)

MEF2C Directly Interacts with Pre-miRNAs and Distinct RNPs to Post-Transcriptionally Regulate miR-23a-miR-27a-miR-24-2 microRNA Cluster Member Expression

Non-Coding RNA
Transcriptional regulation constitutes a key step in gene expression regulation. Myocyte enhancer factor 2C (MEF2C) is a transcription factor of the MADS box family involved in the early development of several cell types, including muscle cells. Over the
Estefanía Lozano-Velasco, Carlos Garcia-Padilla, Miguel Carmona-Garcia, Alba Gonzalez-Diaz, Angela Arequipa-Rendon, Amelia E. Aranega, Diego Franco   +6 more
doaj   +1 more source

Evidence for post-transcriptional regulation of cyclin B1 mRNA in the cell cycle and following irradiation in HeLa cells. [PDF]

, 1995
Amit Maity, W.G. McKenna, Ruth J. Muschel   +2 more
openalex   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

From the regulatory mechanism of TFEB to its therapeutic implications

Cell Death Discovery
Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal expression and regulation (CLEAR) elements. TFEB are regulated by multiple
Huixia Chen, Siqiao Gong, Hongyong Zhang, Yongming Chen, Yonghan Liu, Junfeng Hao, Huafeng Liu, Xiaoyu Li   +7 more
doaj   +1 more source

Post-transcriptional regulation of miRNA biogenesis

, 2019
MicroRNAs (miRNAs) are short non-coding RNA molecules of ~22 nt in length that function as regulators of gene expression. They bind to the 3’ UTR of target mRNAs in a non-perfect complimentary manner, leading to either their degradation or translational repression.
openaire   +4 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

RNA-Protein Binding and Post-transcriptional Regulation of Parathyroid Hormone Gene Expression by Calcium and Phosphate [PDF]

, 1998
Eli Moallem, Rachel Kilav, Justin Silver, Tally Naveh‐Many   +3 more
openalex   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Transcriptional vs post-transcriptional regulation of the central carbon metabolism of E. coli [PDF]

, 2015
Transcriptomics data are currently one of the most available types of large-scale biological data. A large number of methods have been developed to improve constraint-based simulations using these data.
Herrgård, Markus, Machado, C. D., Rocha, I.   +2 more
core  

Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine [PDF]

, 1995
Lisa Parry, Rafael Balaña‐Fouce, Anthony E. Pegg   +2 more
openalex   +1 more source