Results 91 to 100 of about 625,558 (252)

Post-translational modification of OCT4 in breast cancer tumorigenesis

Cell Death and Differentiation, 2018
Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for the lethality of breast cancer.
Yunhee Cho, Hyeokgu Kang, Seok-Jun Kim, Seul Lee, Sujin Jee, S. Ahn, M. Kang, J. Song, J. Chung, E. Yi, Kyung-Hee Chun   +10 more
semanticscholar   +1 more source

T-cell cytotoxicity in the absence of viral protein synthesis in target cells [PDF]

, 1977
CYTOTOXIC T cells lyse only those virus infected target cells in vitro which express, in addition to the viral antigen(s), those K or D region products of the major histocompati-bility complex (MHC) which were present during anti-viral sensitisation in ...
A Munro, A Scheid, BH Sandford, BK Ray, D Aminoff, F Garrido, GI Ada, H Ertl, ID Gardner, J Neff, J Salk, M. J. GETHING, M. WATERFIELD, U Koszinowski, U. KOSZINOWSKI, UK Laemmli, Y Hosaka, Y Ueda, YK Shimizu   +18 more
core   +1 more source

UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2 [PDF]

, 2020
Protein ubiquitination is a very diverse post-translational modification leading to protein degradation or delocalization, or altering protein activity. In Arabidopsis thaliana, two E3 ligases, BIG BROTHER (BB) and DA2, activate the latent peptidases DA1,
Chen, Ying, De Jaeger, Geert, De Milde, Liesbeth, De Vleeschhauwer, Valerie, Eeckhout, Dominique, Gevaert, Kris, Inzé, Dirk, Natran, Annelore, Persiau, Geert, Vanhaeren, Hannes, Vermeersch, Mattias   +10 more
core   +1 more source

Post-translational protein lactylation modification in health and diseases: a double-edged sword

Journal of Translational Medicine
As more is learned about lactate, it acts as both a product and a substrate and functions as a shuttle system between different cell populations to provide the energy for sustaining tumor growth and proliferation.
Hang Gong, Huang Zhong, Long Cheng, Liang-Ping Li, De-Kui Zhang   +4 more
doaj   +1 more source

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources

Potential coordination role between O-GlcNAcylation and epigenetics

Protein & Cell, 2017
Dynamic changes of the post-translational O-GlcNAc modification (O-GlcNAcylation) are controlled by O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) and the glycoside hydrolase O-GlcNAcase (OGA) in cells. O-GlcNAcylation often occurs on serine
Donglu Wu, Yong Cai, Jingji Jin
doaj   +1 more source

Identification of a Post-translational Modification with Ribitol-Phosphate and Its Defect in Muscular Dystrophy.

Cell Reports, 2016
Glycosylation is an essential post-translational modification that underlies many biological processes and diseases. α-dystroglycan (α-DG) is a receptor for matrix and synaptic proteins that causes muscular dystrophy and lissencephaly upon its abnormal ...
M. Kanagawa, Kazuhiro Kobayashi, M. Tajiri, H. Manya, A. Kuga, Y. Yamaguchi, K. Akasaka-Manya, Jun-ichi Furukawa, Mamoru Mizuno, H. Kawakami, Y. Shinohara, Y. Wada, T. Endo, T. Toda   +13 more
semanticscholar   +1 more source

Post-Translational Modifications of Exosomal Proteins

Frontiers in Immunology, 2014
Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection. Exosomes are small vesicles secreted to the extracellular environment through the release of intraluminal vesicles contained in multivesicular bodies (MVBs) upon the fusion of these ...
Olga Moreno-Gonzalo, Carolina Villarroya-Beltri, Francisco Sánchez-Madrid   +2 more
openaire   +5 more sources

Post-Translational Modifications and Diabetes

Biomolecules
Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D).
Chiranjeev Sharma, Abu Hamza, Emily Boyle, Dickson Donu, Yana Cen   +4 more
openaire   +3 more sources

Computational Identification of Post Translational Modification Regulated RNA Binding Protein Motifs. [PDF]

PLoS ONE, 2015
RNA and its associated RNA binding proteins (RBPs) mitigate a diverse array of cellular functions and phenotypes. The interactions between RNA and RBPs are implicated in many roles of biochemical processing by the cell such as localization, protein ...
Andrew S Brown, Bidyut K Mohanty, Philip H Howe   +2 more
doaj   +1 more source