Results 91 to 100 of about 445,929 (364)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Charting the protein complexome in yeast by mass spectrometry [PDF]

, 2002
It has become evident over the past few years that many complex cellular processes, including control of the cell cycle and ubiquitin-dependent proteolysis, are carried out by sophisticated multisubunit protein machines that are dynamic in abundance ...
Cope, Greg, Deshaies, Raymond J., Lyapina, Svetlana, McDonald, W. Hayes, Seol, Jae Hong, Shevchenko, Andrej, Shevchenko, Anna, Verma, Rati, Yates, John R., III   +8 more
core  

Reversible Lysine Acetylation Regulates Activity of Human Glycine N-Acyltransferase-like 2 (hGLYATL2): Implications for Production of Glycine-conjugated Signaling Molecules [PDF]

, 2012
Background: Lysine acetylation is a major post-translational modification of proteins. Results: Human glycine N-acyltransferase-like 2 is regulated by acetylation/deacetylation of lysine 19.
Hunt, Mary, Silberring, Jerzy, Sipos, Laszlo, Sucharski, Filip, Waluk, Dominick P.   +4 more
core   +2 more sources

Global Post-Translational Modification Discovery [PDF]

Journal of Proteome Research, 2017
A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round search of mass spectrometry data with ultrawide precursor mass tolerance.
Qiyao Li, Michael R. Shortreed, Craig D. Wenger, Brian L. Frey, Leah V. Schaffer, Mark Scalf, Lloyd M. Smith   +6 more
openaire   +2 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation [PDF]

, 2016
Cardiac voltage-gated sodium channels (Nav1.5) play an essential role in regulating cardiac electric activity by initiating and propagating action potentials in the heart.
Cummins, Theodore R., Hudmon, Andy, Meng, Jingwei, Pei, Zifan, Xiao, Yucheng   +4 more
core   +1 more source

Asparagine hydroxylation is a reversible post-translational modification [PDF]

, 2020
Amino acid hydroxylation is a common post-translational modification, which generally regulates protein interactions or adds a functional group that can be further modified.
Alex von Kriegsheim, Appelhoff, Araos, Boisvert, Bruick, Cameron D. Haydinger, Chan, Chen, Ciechanover, Cockman, Cockman, Cockman, Cox, Daniel J. Peet, Duan, Giaccia, Gorres, Gray, Hunter, Hutton, Ivan, Jaakkola, Janke, Javier Rodriguez, Karttunen, Kay, Kiriakidis, Kivirikko, Lan K. Nguyen, Lando, Lando, Larance, Loenarz, Luo, Mahon, Mariotti, Maxwell, McMahon, Nguyen, Ohsumi, Oka, Ploumakis, Prass, Ramchandani, Rehder, Rodriguez, Ruan, Schofield, Scholz, Sharp, Singleton, Snell, Tonks, Trewick, Tyanova, Waaler, Walsh, Yang, Yu   +58 more
core   +1 more source

VDAC proteomics: Post-translation modifications

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
Voltage-dependent anion channels are abundant mitochondrial outer membrane proteins expressed in three isoforms, VDAC1-3, and are considered as "mitochondrial gatekeepers". Most tissues express all three isoforms. The functions of VDACs are several-fold, ranging from metabolite and energy exchange to apoptosis.
Charles L. Hoppel, Janos Kerner, Kwangwon Lee, Bernard Tandler   +3 more
openaire   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Toward universal protein post-translational modification detection in high throughput format [PDF]

, 2018
Post-translational modification (PTM) of proteins plays essential regulatory roles in a variety of pathological conditions. Reliable and practical assays are required to accelerate the discovery of inhibitors and activators for PTM related diseases ...
Harma, Harri, Jelesarov, Ilian, Kopra, Kari, Tong-Ochoa, Natalia, van Adrichem, Arjan J., Wennerberg, Krister   +5 more
core   +2 more sources