Results 71 to 80 of about 6,398,571 (341)
Putative post-translational modification sites in wheat AOX proteins.
, 2018 Putative post-translational modification sites in wheat AOX proteins.
Zara B. York (5593592) +4 more
core +1 more source
Post-translational mutagenesis: radical methods for protein modification [PDF]
, 2017 The naturally occurring post-translational modification of proteins expands the chemical and structural diversity available for protein function. Enzymatic processes are known to modify proteins after translation, and in many cases these modifications ...
core +1 more source
Post-translational modifications and their implications in cancer
Frontiers in Oncology, 2023 Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as signal transduction, metabolism, protein localization, and turnover and have clinical relevance in ...
Hashnu Dutta +3 more
openaire +3 more sources
Post-translational modifications of EZH2 in cancer [PDF]
Cell & Bioscience, 2020 AbstractEnhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients. Post-translational modifications (PTMs) are important biological events in cancer progression.
Zhongwei Li +8 more
openaire +3 more sources
Artificial Intelligence Transforming Post-Translational Modification Research
BioengineeringPost-Translational Modifications (PTMs) are covalent changes to amino acids that occur after protein synthesis, including covalent modifications on side chains and peptide backbones.
Doo Nam Kim +8 more
doaj +1 more source
Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics
Biomolecules, 2021 Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP+-dependent oxidation of isocitrate to α-ketoglutarate (αKG). IDH1 mutations, primarily R132H, drive > 80% of low-grade gliomas and secondary glioblastomas and facilitate the NADPH-dependent ...
Joi Weeks +5 more
doaj +1 more source
MoMo: Discovery of statistically significant post-translational modification motifs
bioRxiv, 2018 Motivation Post-translational modifications (PTMs) of proteins are associated with many significant biological functions and can be identified in high throughput using tandem mass spectrometry. Many PTMs are associated with short sequence patterns called
Alice Cheng +3 more
semanticscholar +1 more source
Modification of bacterial microcompartments with target biomolecules via post-translational SpyTagging [PDF]
, 2023 Bacterial microcompartments (BMCs) are proteinaceous organelle-like structures formed within bacteria, often encapsulating enzymes and cellular processes, in particular, allowing toxic intermediates to be shielded from the general cellular environment ...
Smales, C. Mark +16 more
core +1 more source
Post-translational modification of RAS proteins
Current Opinion in Structural Biology, 2021 Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS proteins integrate signals from a wide array of receptors and initiate downstream signaling through pathways that control cellular growth. RAS proteins are fundamentally binary molecular switches in which the off/on state is determined by the binding of GDP or GTP ...
Sharon L, Campbell, Mark R, Philips
openaire +2 more sources
α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation
Nature Communications, 2021 Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting ...
Xuan Xie +9 more
doaj +1 more source