Results 91 to 100 of about 6,398,571 (341)
O-GLCNAC Post Translational Modification of Hypoxia-Inducible Factor (HIF) Proteins [PDF]
, 2018 O-linked β-N-acetylglucosamine (O-GlcNAc) post-translational modification (O- GlcNAcylation), plays a vital role in many metabolic pathways, including those of numerous diseases.
Grisham, Hailey Elisabeth
core +2 more sources
Current Understanding of SIRT7 Function and Its Emerging Roles in the Central Nervous System
CellsSIRT7is an NAD+-dependent deacetylase predominantly localized in the nucleolus, where it plays important roles in chromatin regulation, transcriptional control, and cellular stress response.
Yuchen Jiao +2 more
doaj +1 more source
Post-translational Modification Control of HBV Biological Processes
Frontiers in Microbiology, 2018 Hepatitis B virus infection remains a global healthy issue that needs to be urgently solved. Novel strategies for anti-viral therapy are based on exploring the effective diagnostic markers and therapeutic targets of diseases caused by hepatitis B virus ...
Fan Yang
doaj +1 more source
Capsule network for protein post-translational modification site prediction
Bioinform., 2018 Motivation Computational methods for protein post-translational modification (PTM) site prediction provide a useful approach for studying protein functions. The prediction accuracy of the existing methods has significant room for improvement.
Duo-Lin Wang, Yan-Chun Liang, Dong Xu
semanticscholar +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification
, 2009 Frese M-A, Dierks T. Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification. CHEMBIOCHEM. 2009;10(3):425-427.Oxidation of a specific cysteine residue to C(alpha)-formylglycine is a novel post-translational ...
Thomas Dierks +3 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Global Post-Translational Modification Discovery
, 2017 A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round ...
Michael R. Shortreed (200226) +6 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death.
Cell Reports, 2019 Linear ubiquitination has emerged as an important post-translational modification that regulates NF-κB activation, inflammation, and cell death in both immune and non-immune compartments, including the skin.
T. Douglas, M. Saleh
semanticscholar +1 more source