Results 91 to 100 of about 312,553 (300)
Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
, 2011 β2AR (β2 adrenoceptor) is a prototypical G-protein coupled receptor (GPCR) that plays an important role in cardiovascular and pulmonary physiology through activation of the classic Gs-adenylate cyclase-cyclic adenosine monophosphate (cAMP)-protein kinase
Liu, Ruijie
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Functional Polymers by Post-Polymerization Modification: Concepts, Guidelines, and Applications
In modern polymer science a variety of polymerization methods for the direct synthesis of polymers bearing functional groups are known. However, there is still a large number of functional groups that may either completely prevent polymerization or lead ...
Klok, Harm Anton, Theato, Patrick
core +1 more source
Post-translational modification of proteins [PDF]
, 2018 Posttranslacijska modifikacija svaka je preinaka proteina koja se odvija na proteinu nakon njegove biosinteze. Ove modifikacije uključuju smatanje proteina te mnogobrojne kovalentne modifikacije.
Valla, Robert
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Protein post-translational modification regulates HIV-1 latency
生物医学转化AIDS is a disease named acquired immunodeficiency syndrome, which caused by the human immunodeficiency virus (HIV). HIV can be divided into HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is a global pandemic that has caused serious harm.
Wu Tong, Wang Tiantian, Deng Kai
doaj +1 more source
, 2012 Recent efforts in biomolecular event extraction have mainly focused on core event types involving genes and proteins, such as gene expression, protein-protein interactions, and protein catabolism.
Björne, Jari +15 more
core
Post-Translational Modification Mimicry for Programmable Assembly of Elastin-Based Protein Polymers
, 2020 Post-translational modification (PTM) of protein polymers is emerging as a powerful bioinspired strategy to create protein-based hybrid materials with molecularly encoded assembly and function for applications in nanobiotechnology and medicine.
Dieter M. Scheibel (8479746) +9 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source