Results 131 to 140 of about 625,558 (252)

Immunoinflammation and post-translational modifications in the aging process

Journal of Translational Medicine
Aging is an intrinsic biological decline marked by multidimensional alterations spanning molecular, cellular, tissue, and organ levels. One hallmark of aging is the progressive deterioration of immune function, a condition referred to as immunosenescence.
Jiaqi Xiao, Xuan Qin, WenTao Chen, Xinyu Que, Yaoyao Ma, Wentao Huang, Haoxiang Ou, Yongfen Bao, Lihua Qu, Shigang Shan   +9 more
doaj   +1 more source

Poly(ADP-Ribosyl)ation affects stabilization of CHE-1 protein in response to DNA damage [PDF]

, 2011
Post-translation modifications play a crucial role in coordinating the cellular response to DNA damage. Double strand DNA breaks (DSBs) trigger the activation of ATM and Chk2 kinases, which represent the primary transducers in the signalling cascade ...
BACALINI, MARIA GIULIA
core  

SnRK2s: Kinases or Substrates?

Plants
Throughout their life cycle, plants persistent through environmental adversities that activate sophisticated stress-signaling networks, with protein kinases serving as pivotal regulators of these responses.
Yunmin Wei, Linzhu Peng, Xiangui Zhou
doaj   +1 more source

Modulation of Rab GTPase function by a protein phosphocholine transferase. [PDF]

, 2011
The intracellular pathogen Legionella pneumophila modulates the activity of host GTPases to direct the transport and assembly of the membrane-bound compartment in which it resides.
Arasaki, Kohei, Galán, Jorge E, Liu, Xiaoyun, McDonough, Justin, Mukherjee, Shaeri, Roy, Craig R   +5 more
core  

Functional significance of O-linked N-acetylglucosamine protein modification in regulating autophagy

Pharmacological Research
Autophagy is a core molecular pathway that preserves cellular and organismal homeostasis. Being susceptible to nutrient availability and stress, eukaryotic cells recycle or degrade internal components via membrane transport pathways to provide ...
Zhuang Zhu, Wenhao Ren, Shaoming Li, Ling Gao, Keqian Zhi   +4 more
doaj   +1 more source

Post-translational modifications in prion diseases

Frontiers in Molecular Neuroscience
More than 650 reversible and irreversible post-translational modifications (PTMs) of proteins have been listed so far. Canonical PTMs of proteins consist of the covalent addition of functional or chemical groups on target backbone amino-acids or the cleavage of the protein itself, giving rise to modified proteins with specific properties in terms of ...
Chloé Bizingre, Chloé Bizingre, Clara Bianchi, Clara Bianchi, Anne Baudry, Anne Baudry, Aurélie Alleaume-Butaux, Aurélie Alleaume-Butaux, Benoit Schneider, Benoit Schneider, Benoit Schneider, Mathéa Pietri, Mathéa Pietri   +12 more
openaire   +5 more sources

HDACs and Their Inhibitors on Post-Translational Modifications: The Regulation of Cardiovascular Disease

Cells
Cardiovascular diseases (CVD), such as myocardial hypertrophy, heart failure, atherosclerosis, and myocardial ischemia/reperfusion (I/R) injury, are among the major threats to human health worldwide. Post-translational modifications alter the function of
Siyi Yang, Yidong Sun, Wei Yu
doaj   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science
Parallel to their roles in regulating receptor activation, mounting evidence suggests that monoamines are involved in protein post‐translational modification, which regulates the physiological function of the nervous system and various ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
doaj   +1 more source

Post-translational modifications in drug resistance

Drug Resistance Updates
Resistance to antitumor drugs, antimicrobial drugs, and antiviral drugs severely limits treatment effectiveness and cure rate of diseases. Protein post-translational modifications (PTMs) represented by glycosylation, ubiquitination, SUMOylation, acetylation, phosphorylation, palmitoylation, and lactylation are closely related to drug resistance.
Chenggui, Miao, Yurong, Huang, Cheng, Zhang, Xiao, Wang, Bing, Wang, Xinyue, Zhou, Yingqiu, Song, Peng, Wu, Zhe-Sheng, Chen, Yibin, Feng   +9 more
openaire   +2 more sources

Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]

, 2015
Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core