Results 151 to 160 of about 468,017 (309)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

HDACs and Their Inhibitors on Post-Translational Modifications: The Regulation of Cardiovascular Disease

Cells
Cardiovascular diseases (CVD), such as myocardial hypertrophy, heart failure, atherosclerosis, and myocardial ischemia/reperfusion (I/R) injury, are among the major threats to human health worldwide. Post-translational modifications alter the function of
Siyi Yang, Yidong Sun, Wei Yu
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science
Parallel to their roles in regulating receptor activation, mounting evidence suggests that monoamines are involved in protein post‐translational modification, which regulates the physiological function of the nervous system and various ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
doaj   +1 more source

A hangulatstabilizáló gyógyszerek (lítium, valproinsav, karbamazepin) hatásai a kalcium ionok által közvetített intracelluláris jelátvitelre = Effects of mood stabilizer drugs (lithium, valproic acid, carbamazepine) on the calcium ion mediated intracellular signal transduction [PDF]

, 2012
A lítium bipoláris betegek kezelésére használt gyógyszer, azonban pontos hatásmechanizmusa máig nem tisztázott. Korábbi kutatásokból ismert, hogy a lítium gátolja a foszfoglukomutázt, mely a galaktóz metabolizmus egyik kulcsenzime.
Fekete, Sándor, Kovács L., Gábor, Miseta, Attila, Nagy, Tamás, Osváth, Péter, Poór, Viktor Soma, Rideg, Orsolya, Sipos, Katalin   +7 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Post-translational modifications in drug resistance

Drug Resistance Updates
Resistance to antitumor drugs, antimicrobial drugs, and antiviral drugs severely limits treatment effectiveness and cure rate of diseases. Protein post-translational modifications (PTMs) represented by glycosylation, ubiquitination, SUMOylation, acetylation, phosphorylation, palmitoylation, and lactylation are closely related to drug resistance.
Chenggui, Miao, Yurong, Huang, Cheng, Zhang, Xiao, Wang, Bing, Wang, Xinyue, Zhou, Yingqiu, Song, Peng, Wu, Zhe-Sheng, Chen, Yibin, Feng   +9 more
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The Deletion of the Bre1 Gene in Aspergillus nidulans Impairs Mitotic Growth, Meiosis, and DNA Damage Repair

, 2013
Bre1 is a homotetrameric E3 ubiquitin-protein ligase that heterodimerizes with Rad6, an E2 ubiquitin-conjugating enzyme, in order to ubiquitinate lysine 123 in Aspergillus nidulans.
James, Steven W., Sitton, Andrea J.
core  

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source