Results 131 to 140 of about 312,553 (300)

Post‐translational modifications in diabetic cardiomyopathy

Journal of Cellular and Molecular Medicine
AbstractThe increasing attention towards diabetic cardiomyopathy as a distinctive complication of diabetes mellitus has highlighted the need for standardized diagnostic criteria and targeted treatment approaches in clinical practice. Ongoing research is gradually unravelling the pathogenesis of diabetic cardiomyopathy, with a particular emphasis on ...
Zhi Li, Jie Chen, Hailong Huang, Qianru Zhan, Fengzhi Wang, Zihan Chen, Xinwei Lu, Guozhe Sun   +7 more
openaire   +2 more sources

Signaling by hydrogen sulfide and cyanide through post-translational modification

, 2019
Two cysteine metabolism-related molecules, hydrogen sulfide and hydrogen cyanide, which are considered toxic, have now been considered as signaling molecules.
Gotor Martínez, Cecilia, Moreno González, Inmaculada, Laureano Marín, Ana María, Romero González, Luis Carlos, Gotor, Cecilia, Arenas Alfonseca, Lucía, Laureano-Marín, Ana M., Romero, Luis C., Aroca Aguilar, Ángeles, Jurado-Flores, Ana, Moreno, Inmaculada, Arenas-Alfonseca, Lucía, Jurado Flores, Ana, García Fernández, Irene, Aroca, Ángeles   +14 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification

, 2009
Frese M-A, Dierks T. Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification. CHEMBIOCHEM. 2009;10(3):425-427.Oxidation of a specific cysteine residue to C(alpha)-formylglycine is a novel post-translational ...
Thomas Dierks, Dierks, Thomas, Frese, Marc-Andre, Marc‐André Frese   +3 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Subcellular differences in post-translational modification of barley 14-3-3 proteins

, 2000
Expression and post-translational modification of barley 14-3-3 isoforms, 14-3-3A, 14-3-3B and 14-3-3C, were investigated using isoform-specific antibodies.
Jan W. Kijne, Testerink, Christa, Christa Testerink, Zeijl, Mieke J., Van, Wang, Mei, Mei Wang, Kijne, Jan W., Mieke J. van Zeijl, van Zeijl, Mieke J.   +8 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Functional significance of O-linked N-acetylglucosamine protein modification in regulating autophagy

Pharmacological Research
Autophagy is a core molecular pathway that preserves cellular and organismal homeostasis. Being susceptible to nutrient availability and stress, eukaryotic cells recycle or degrade internal components via membrane transport pathways to provide ...
Zhuang Zhu, Wenhao Ren, Shaoming Li, Ling Gao, Keqian Zhi   +4 more
doaj   +1 more source

Molecular Mechanism for Eliminylation, a Newly Discovered Post-Translational Modification

, 2016
The newly discovered bacterial phosphothreonine lyases perform a post-translational modification of host cell signaling proteins through a novel catalytic mechanism that irreversibly removes the phosphate group from a phosphorylated threonine via β ...
Gregory K. Smith (2180700), Zhihong Ke (2180698), Hua Guo (305546), Yingkai Zhang (1292472)   +3 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source