Results 171 to 180 of about 312,553 (300)
Histone H3 Post-Translational Modification Changes are Linked to Manganese and Copper Exposure in <i>Saccharomyces cerevisiae</i>. [PDF]
MicroPubl BiolVillasi W +5 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Protein mannosylation in actinobacteria an enigmatic post-translational modification. [PDF]
RSC Chem BiolKing CB, Wakarchuk WW.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
Journal of Inflammation ResearchJingkai Tang,1,* Yiwei Zhang,1,* Yibing Wang,1,* Yanxin Fu,1 Jingman Qi,1 Aomeng Xiang,1 Ruoxuan Zhao,1 Ge Tan,1 Huili Deng,2 Xuchang Zhou,2 Liang Wu3 1Department of Sport Rehabilitation, Tianjin University of Sport, Tianjin ...
Tang J +10 more
doaj
Decoding the Post-translational Modification Crosstalk: Functional Implications of Phosphorylation, Acetylation, and Methylation. [PDF]
J Phys Chem BQin X, Nangia S.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie +8 more
wiley +1 more source
Post-translational modification signature shapes the tumor immune microenvironment and predicts clinical outcomes in melanoma. [PDF]
Discov OncolLin T, Fu B, Lu X.
europepmc +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
DeepPTMPred: a multi-modal deep learning framework for accurate prediction of protein post-translational modification sites. [PDF]
Brief BioinformWang C +9 more
europepmc +1 more source