Results 61 to 70 of about 445,929 (364)

Online Modifications for Event-based Signal Temporal Logic Specifications [PDF]

arXiv, 2023
In this paper we present a grammar and control synthesis framework for online modification of Event-based Signal Temporal Logic (STL) specifications, during execution. These modifications allow a user to change the robots' task in response to potential future violations, changes to the environment, or user-defined task design changes.
arxiv  

Smc5/6: a link between DNA repair and unidirectional replication? [PDF]

, 2008
Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication.
A Losada, Antony M. Carr, AR Lehmann, B Hu, D Branzei, D Ivanov, DM Sheedy, E Ampatzidou, E Unal, E Unal, EA Andrews, ES Chen, F Onoda, G De Piccoli, GJ Cost, H Morikawa, HB Lindroos, HM Verkade, I Miyabe, J Palecek, J Rouse, J Sergeant, J Torres-Rosell, J Torres-Rosell, JK Chin, Johanne M. Murray, KL Borden, KM Lee, L Strom, L Strom, MI Fousteri, MN Boddy, N Aono, PR Potts, PR Potts, PR Potts, S Pebernard, S Pebernard, SH Harvey, T de Lange, T Kobayashi, T Mengiste, T Morishita, TM Roberts, WH McDonald, WM Thorburn, X Zhao   +46 more
core   +1 more source

Dynamics of post-translational modification systems: recent progress and future directions

, 2017
Post-translational modification (PTM) of proteins plays a key role in signal transduction, and hence significant effort has gone toward understanding how PTM networks process information. This involves, on the theory side, analyzing the dynamical systems
Conradi, Carsten, Shiu, Anne
core   +1 more source

Insights into Regulators of p53 Acetylation

Cells, 2022
The tumor suppressor p53 is a transcription factor that regulates the expression of dozens of target genes and diverse physiological processes. To precisely regulate the p53 network, p53 undergoes various post-translational modifications and alters the ...
Mai Nagasaka, Chiharu Miyajima, Hiromasa Aoki, Mineyoshi Aoyama, Daisuke Morishita, Yasumichi Inoue, Hidetoshi Hayashi   +6 more
doaj   +1 more source

Multiway Storage Modification Machines [PDF]

arXiv, 2021
We present a parallel version of Sch\"onhage's Storage Modification Machine, the Multiway Storage Modification Machine (MWSMM). Like the alternative Association Storage Modification Machine of Tromp and van Emde Boas, MWSMMs recognize in polynomial time what Turing Machines recognize in polynomial space.
arxiv  

Post-Translational Modifications and Diabetes

Biomolecules
Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D).
Chiranjeev Sharma, Abu Hamza, Emily Boyle, Dickson Donu, Yana Cen   +4 more
openaire   +3 more sources

Absolute quantitation of post-translational modifications [PDF]

Frontiers in Chemistry, 2014
The cell's fate is largely governed by the dynamics of cellular events, brought about by the interplay of various proteins, in which post-translational modifications (PTMs) play a key role. Therefore, a better understanding of post-translational modification is of utmost importance to a biochemist.
openaire   +4 more sources

Post-translational modifications on the retinoblastoma protein

Journal of Biomedical Science, 2022
AbstractThe retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours. The functions of pRb are tightly regulated, where post-translational modifications (PTMs) play crucial roles, including phosphorylation ...
Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang, Wai Kit Chu   +6 more
openaire   +3 more sources

Post-translational modification of proteins [PDF]

, 2018
Posttranslacijska modifikacija svaka je preinaka proteina koja se odvija na proteinu nakon njegove biosinteze. Ove modifikacije uključuju smatanje proteina te mnogobrojne kovalentne modifikacije.
Valla, Robert
core   +2 more sources

Functional divergence in the role of N-linked glycosylation in smoothened signaling [PDF]

, 2015
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have ...
A Helenius, A Ruiz i Altaba, AG Soto, AG Soto, AH Polizio, AH Polizio, AJ Petrescu, AJ Zhu, AM Wilbanks, Angela M. Arensdorf, Ashley Truong, B Sivertsen, BJ Arey, BR Myers, C Torroja, C Wang, C Wang, CE Carroll, D Maier, D Nedelcu, D Rendie, D Shi, Daniel P. Stewart, David J. Robbins, DJ Casso, DJ Robbins, DM Stone, Edgar Angelats, F Landomiel, F Shen, G Navarro, Gemma Navarro, H Sasaki, J Alcedo, J Bischof, J Briscoe, J He, J Taipale, J Taipale, JD Violin, JJ Kovacs, JK Chen, JK Chen, Joseph T. Opferman, JP Incardona, KC Corbit, L Zhou, LW McGinnes, M Murone, M van den Heuvel, M Wheatley, MF Tansky, MT Barakat, N Denef, NA Riobo, Peter J. McCormick, PM Lanctot, PW Ingham, R Rana, R Rohatgi, R Rohatgi, R Schroder, R Schroder, R Teperino, R Xia, Rajat Rohatgi, RT Strachan, S Li, S Marada, S Mukhopadhyay, S Nachtergaele, S Nachtergaele, S Rajagopal, S Yao, Sigrid Nachtergaele, SK Ogden, Stacey K. Ogden, Suresh Marada, T Von Ohlen, V Marigo, X Lu, Y Nakano, Y Zhao, YH Belgacem   +83 more
core   +3 more sources