Results 71 to 80 of about 445,929 (364)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Post-translational Modification Control of HBV Biological Processes
Frontiers in Microbiology, 2018 Hepatitis B virus infection remains a global healthy issue that needs to be urgently solved. Novel strategies for anti-viral therapy are based on exploring the effective diagnostic markers and therapeutic targets of diseases caused by hepatitis B virus ...
Fan Yang
doaj +1 more source
Quantitative analysis of the human T cell palmitome [PDF]
, 2015 Palmitoylation is a reversible post-translational modification used to inducibly compartmentalize proteins in cellular membranes, affecting the function of receptors and intracellular signaling proteins.
Brügger, Britta +5 more
core +1 more source
Synthetic post-translational modification of histones [PDF]
Current Opinion in Chemical Biology, 2018 Chromatin is the physiological template of genetic information in all eukaryotic cells, a highly organised complex of DNA and histone proteins central in regulating gene expression and genome organisation. A multitude of histone post-translational modifications (PTMs) have been discovered, providing a glance into the complex interplay of these ...
Simon Nadal +3 more
openaire +3 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Post-translational modification of PII signal transduction proteins
Frontiers in Microbiology, 2015 The PII proteins constitute one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite
Mike eMerrick
doaj +1 more source
A Proposal on Quantum Histone Modification in Gene Expression [PDF]
, 2012 A quantum mechanical model on histone modification is proposed. Along with the methyl / acetate or other groups bound to the modified residues the torsion angles of the nearby histone chain are supposed to participate in the quantum transition cooperatively.
arxiv +1 more source
Evaluating the robustness of source code plagiarism detection tools to pervasive plagiarism-hiding modifications [PDF]
arXiv, 2021 Source code plagiarism is a common occurrence in undergraduate computer science education. In order to identify such cases, many source code plagiarism detection tools have been proposed. A source code plagiarism detection tool evaluates pairs of assignment submissions to detect indications of plagiarism.
arxiv
Monopoles and Modifications of Bundles over Elliptic Curves [PDF]
SIGMA 5 (2009), 065, 22 pages, 2008 Modifications of bundles over complex curves is an operation that allows one to construct a new bundle from a given one. Modifications can change a topological type of bundle. We describe the topological type in terms of the characteristic classes of the bundle. Being applied to the Higgs bundles modifications establish an equivalence between different
arxiv +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source