Results 101 to 110 of about 541,798 (360)

Global Post-Translational Modification Discovery [PDF]

Journal of Proteome Research, 2017
A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round search of mass spectrometry data with ultrawide precursor mass tolerance.
Qiyao Li, Michael R. Shortreed, Craig D. Wenger, Brian L. Frey, Leah V. Schaffer, Mark Scalf, Lloyd M. Smith   +6 more
openaire   +2 more sources

Maturation of nuclear lamin A involves a specific carboxy-terminal trimming, which removes the polyisoprenylation site from the precursor; implications for the structure of the nuclear lamina. [PDF]

, 1989
Lamin A, a nuclear lamina protein of differentiated cells, is synthesized as a precursor of the mature molecule. Protein sequencing of the carboxyterminal 14 kDa fragment shows a lack of the last 18 residues predicted by cDNA sequencing.
Plessmann, U., Traub, P., Weber, K.
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

VDAC proteomics: Post-translation modifications

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
Voltage-dependent anion channels are abundant mitochondrial outer membrane proteins expressed in three isoforms, VDAC1-3, and are considered as "mitochondrial gatekeepers". Most tissues express all three isoforms. The functions of VDACs are several-fold, ranging from metabolite and energy exchange to apoptosis.
Charles L. Hoppel, Janos Kerner, Kwangwon Lee, Bernard Tandler   +3 more
openaire   +3 more sources

Towards a Universal Translator: Decoding the PTMs That Regulate Orthoflavivirus Infection

Viruses
Post-translational modifications (PTMs) serve as critical regulators of protein function across biological systems, including during viral infection. For orthoflaviviruses, including human pathogens like dengue, Zika, and West Nile viruses, PTMs on viral
Hannah M. Schmidt, Stacy M. Horner
doaj   +1 more source

Post-translational modifications of histones in vertebrate neurogenesis

Frontiers in Neuroscience, 2015
The process of neurogenesis, through which the entire nervous system of an organism is formed, has attracted immense scientific attention for decades. How can a single neural stem cell give rise to astrocytes, oligodendrocytes and neurons?
Nikolaos eMitrousis, Vincent eTropepe, Vincent eTropepe, Ola eHermanson   +3 more
doaj   +1 more source

Redox signaling, Nox5 and vascular remodeling in hypertension [PDF]

, 2015
Purpose of review: Extensive data indicate a role for reactive oxygen species (ROS) and redox signaling in vascular damage in hypertension. However, molecular mechanisms underlying these processes remain unclear, but oxidative post-translational ...
De Lucca Camargo, Livia, Dulak-Lis, Maria, Harvey, Adam, Montezano, Augusto C., Touyz, Rhian M., Tsiropoulou, Sofia   +5 more
core   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

The identification of carbon dioxide mediated protein post-translational modifications

Nature Communications, 2018
Carbon dioxide can interact with proteins to form carbamate post-translational modifications. Here, the authors developed a strategy to identify carbamate post-translational modifications by trapping carbon dioxide and subsequently identifying the ...
Victoria L. Linthwaite, Joanna M. Janus, Adrian P. Brown, David Wong-Pascua, AnnMarie C. O’Donoghue, Andrew Porter, Achim Treumann, David R. W. Hodgson, Martin J. Cann   +8 more
doaj   +1 more source

Modulation of rat brain calpastatin efficiency by post-translational modifications [PDF]

, 1997
Calpains, the thiol proteinases of the calcium-dependent proteolytic system, are regulated by a natural inhibitor, calpastatin, which is present in brain tissue in two forms. Although both calpastatins are highly active on human erythrocyte calpain, only
Averna, Monica, De Tullio, Roberta, Melloni, Edon, Pontremoli, Sandro, Salamino, Franca, Tedesco, Ilaria   +5 more
core   +1 more source