Results 251 to 260 of about 76,851 (293)

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

The deubiquitinase inhibitor WP1130 drives nuclear aggregation and reactivation of mutant p53 for selective cancer cell targeting

The FEBS Journal, Volume 292, Issue 11, Page 2823-2842, June 2025.
Targeting the stability of oncogenic mutant p53 (mutp53) presents a promising strategy for cancer therapy. This study identifies the deubiquitinases (DUBs) USP5 and USP9X as key regulators of mutp53 stability. The DUB inhibitor WP1130 selectively destabilized mutp53 by promoting its ubiquitination, nuclear aggregation, and degradation via the ...
Swapnil Oak, Onkar Karajgikar, Nikhil Gadewal, Prasad Sulkshane, Tripti Verma, Sanjay Gupta, Tanuja Teni   +6 more
wiley   +1 more source

Alzheimer disease-associated tau post-translational modification mimics impact tau propagation and uptake. [PDF]

J Neuropathol Exp Neurol
Dickson JR, Sobolewski RGR, Fernandes AR, Cooper JM, Fan Z, Chung M, Donahue C, Oakley DH, Strickland DK, Hyman BT.   +9 more
europepmc   +1 more source

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, Volume 292, Issue 11, Page 2865-2881, June 2025.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

Dynamic metabolic regulation of histone modifications during the yeast metabolic cycle. [PDF]

PLoS One
Guzmán-Dinamarca B, Conejeros R, Rivas-Astroza M.   +2 more
europepmc   +1 more source

Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase

The FEBS Journal, Volume 292, Issue 12, Page 3151-3164, June 2025.
This study reveals the interaction between minichromosome maintenance protein 6 (MCM6) and Bloom syndrome helicase (BLM), which is essential for DNA replication and cancer progression. Using fluorescence polarization anisotropy and NMR, we show the MCM6 winged‐helix domain (WHD) binds to the MCM6 binding domain D (MBD‐D) of BLM. MCM6 and BLM expression
Min June Yang, Haeun Lee, Donguk Kang, Chin‐Ju Park   +3 more
wiley   +1 more source

PTMVision: An Interactive Visualization Webserver for Post-translational Modifications of Proteins. [PDF]

J Proteome Res
Hackl S, Jachmann C, Witte Paz M, Harbig TA, Martens L, Nieselt K.   +5 more
europepmc   +1 more source

SMYD2 Promotes Renal Tubular Cell Apoptosis and Chronic Kidney Disease Following Cisplatin Nephrotoxicity

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
SMYD2 mediates the activation of the NF‐κB signaling pathway to promote cisplatin‐induced chronic kidney injury. Cisplatin stimulation induces the upregulation of SMYD2 expression in renal tubular epithelial cells. SMYD2 promotes the phosphorylation of the p65 subunit of NF‐κB through methylation, thereby facilitating the release of inflammatory ...
Siyang Zuo, Huixiong Yuan, Xia Li, Ming Chen, Rui Peng, Siyu Chen, Xue Zou, Yuan Yang, Hehua Long, Zeying Liu, Teng Wang, Bing Guo, Lirong Liu   +12 more
wiley   +1 more source

Post-translational modifications in hepatocellular carcinoma: unlocking new frontiers in immunotherapy. [PDF]

Front Immunol
Piao Y, Zhai N, Zhang X, Zhao W, Li M.
europepmc   +1 more source

Convergent Assembly of Homo‐ and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol‐Ene Chemistry

Angewandte Chemie International Edition, Volume 64, Issue 21, May 19, 2025.
Generating functionalized ubiquitin building blocks via expression in E. coli paves the way to different di‐, tri‐, and tetra‐ubiquitin chains. Light‐induced thiol‐ene click reactions, combined with a masking and protection strategy, are harnessed to establish controlled ubiquitin chain assembly and to allow the semisynthesis of site‐selectively ...
Moritz Urschbach, Susanne Huhmann, Dominik Appel, Luca Ferrari, Dominik Vogl, Sascha Martens, Christian F. W. Becker   +6 more
wiley   +1 more source