Results 251 to 260 of about 41,962 (282)

Targeting the Dynamics Between TAMs and CAR‐T Cells in Solid Tumor Therapies

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This review highlights the critical role of tumor‐associated macrophages (TAMs) in affecting CAR‐T cell therapy effectiveness in solid tumors. TAMs contribute to immune suppression through cytokine secretion, immune checkpoint activation, and metabolic reprogramming, leading to CAR‐T cell exhaustion and reduced efficacy. The article explores strategies
Xiang Zhang, Hao Zheng, Zi‐Chang Liu, Ling‐Jie Luo, Xiao Dong, Xin‐Gang Cui, Yan‐Wei Wu, Liang Chen   +7 more
wiley   +1 more source

Mechanistic insights into post-translational modifications in hepatic fibrosis: pathogenic roles and therapeutic potentials. [PDF]

J Transl Med
Bai X, Liu Z, Li X, Sun R, Yu Z.
europepmc   +1 more source

GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Glutathione (GSH) defines oxidative balance, but can it directly tune central metabolism? The research reveals that GSH binds and potently activates pyruvate kniase M2 (PKM2), rewiring glycolysis and dictating ferroptosis sensitivity. Combining GSH depletion with PKM2 activation triggers mitochondrial damage and lipid peroxidation, profoundly ...
Tsan‐Jan Chen, Chi‐Jen Lo, Meng‐Jen Wu, Wei Yang Sit, Hsin‐Yu Hsu, Yi‐Cheng Huang, Chien‐Hung Lu, Yu‐Lun Chen, Wei‐Kai Fang, Shan‐Min Yang, Pei‐Lien Chen, Tokuko Haraguchi, Yasushi Hiraoka, Chun‐Yu Lin, Mei‐Ling Cheng, Muh‐Hwa Yang, Hsing‐Jien Kung, Wen‐Ching Wang   +17 more
wiley   +1 more source

Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications. [PDF]

World J Stem Cells
Shi ZJ, Liu W.
europepmc   +1 more source

TDP‐43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP‐43 Aggregation in Neurodegenerative Diseases?

BioEssays, Volume 48, Issue 1, January 2026.
TDP‐43 hyperphosphorylation occurs in neurodegenerative diseases, however, it is not a driver of TDP‐43 aggregation, but enhances TDP‐43 solubility, suggesting that TDP‐43 hyperphosphorylation is protective. Toxicity may arise from a broader phosphorylation‐driven cellular pathway disruption.
Simone Mosna, Dorothee Dormann
wiley   +1 more source

Antigenic Dark Matter: Unexplored Post-Translational Modifications of Tumor-Associated and Tumor-Specific Antigens in Pancreatic Cancer. [PDF]

Cancers (Basel)
Safa A, Vruzhaj I, Gambirasi M, Toffoli G.   +3 more
europepmc   +1 more source

Where, When, and How? Integrating Spatiotemporal Cues in Cell Division

BioEssays, Volume 48, Issue 1, January 2026.
Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo, Hradini Konthalapalli, Claudio Alfieri, Jonathon Pines   +3 more
wiley   +1 more source

Single-cell and spatial transcriptomics reveal post-translational modifications in osteosarcoma progression and tumor microenvironment. [PDF]

PLoS One
Cui Y, Wu Y, Jiang D, Ding T.
europepmc   +1 more source

Reprogramming Fibrosis: How Protein PTMs Reshape the IPF Proteome. [PDF]

Genes (Basel)
Li Y, Kong W, Zhang H, Wei X, Yi J, Wang M, Jin S, Yu D.   +7 more
europepmc   +1 more source

Oxidative stress: a new player in the regulation of AGO1 homeostasis? [PDF]

J Exp Bot
Jullien PE, Molinier J.
europepmc   +1 more source