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PTM-X: Prediction of Post-Translational Modification Crosstalk Within and Across Proteins
2022Posttranslational modifications (PTMs), which are processes of adding covalent groups in protein amino acids after the translation, play an important role in regulating proteins' localization, degradation, and functions. Different PTMs both within a single protein and across multiple proteins can work together or regulate reciprocally, known as PTM ...
Yuxuan, Li, Yuanhua, Huang, Tingting, Li
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[Post-translational modification (PTM) bioinformatics in China: progresses and perspectives].
Yi chuan = Hereditas, 2015Post-translational modifications (PTMs) are essential for regulating conformational changes, activities and functions of proteins, and are involved in almost all cellular pathways and processes. Identification of protein PTMs is the basis for understanding cellular and molecular mechanisms.
Lu Xie +13 more
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Mass Spectrometric Analysis of Post-translational Modifications (PTMs) and Protein–Protein Interactions (PPIs) [PDF]
, 2014 Of the 25,000-30,000 human genes, about 2 % code for proteins. However, there are about one to two million protein entities. This is primarily due to alternative splicing and post-translational modifications (PTMs). Identifying all these modifications in one proteome at a particular time point during development or during the transition from normal to ...
Costel C. Darie +2 more
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Journal of Proteomics, 2023
Myocardial infarction (MI) leading to heart failure contributes to almost 85% of deaths associated with CVDs. MI results from plaque formation in the coronary artery which leads to a lack of oxygen and nutrients in the myocardium. To date, stenting is a widely used gold-standard technique to maintain the proper blood flow through coronary circulation ...
Vivek, Sarohi, Trayambak, Basak
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Myocardial infarction (MI) leading to heart failure contributes to almost 85% of deaths associated with CVDs. MI results from plaque formation in the coronary artery which leads to a lack of oxygen and nutrients in the myocardium. To date, stenting is a widely used gold-standard technique to maintain the proper blood flow through coronary circulation ...
Vivek, Sarohi, Trayambak, Basak
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Study of Post-Translational Modifications (PTMs) with Max Quant software
2022Post-translational modifications are covalent processing events that alter the function of the protein by adding a modifying group to one or more amino acids. Their detection and quantification are particularly challenging. We set up parameters that allowed us to detect glycosylation and acetylation by using an Orbitrab LC-MS/MS and we processed the ...
Beatrice Aiuto +7 more
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PROTEOMICS, 2013
Mass spectrometry (MS) analysis of peptides carrying post‐translational modifications is challenging due to the instability of some modifications during MS analysis. However, glycopeptides as well as acetylated, methylated and other modified peptides release specific fragment ions during CID (collision‐induced dissociation) and HCD (higher energy ...
Nanni, Paolo +5 more
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Mass spectrometry (MS) analysis of peptides carrying post‐translational modifications is challenging due to the instability of some modifications during MS analysis. However, glycopeptides as well as acetylated, methylated and other modified peptides release specific fragment ions during CID (collision‐induced dissociation) and HCD (higher energy ...
Nanni, Paolo +5 more
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2021
In this chapter, we describe the proteomic approach named "Native Chromatin Proteomics" (N-ChroP) that couples a modified Chromatin ImmunoPrecipitation (ChIP) protocol with the mass spectrometry (MS) analysis of immunoprecipitated proteins to study the combinatorial enrichment or exclusion of histone post-translational modifications (PTMs) at specific ...
Nicosia L, Bonaldi T
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In this chapter, we describe the proteomic approach named "Native Chromatin Proteomics" (N-ChroP) that couples a modified Chromatin ImmunoPrecipitation (ChIP) protocol with the mass spectrometry (MS) analysis of immunoprecipitated proteins to study the combinatorial enrichment or exclusion of histone post-translational modifications (PTMs) at specific ...
Nicosia L, Bonaldi T
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Proteins: Structure, Function, and Bioinformatics, 2016
ABSTRACTPost‐translational modifications (PTMs) represent an important regulatory layer influencing the structure and function of proteins. With broader availability of experimental information on the occurrences of different PTM types, the investigation of a potential “crosstalk” between different PTM types and combinatorial effects have moved into ...
Korkuc, P., Walther, D.
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ABSTRACTPost‐translational modifications (PTMs) represent an important regulatory layer influencing the structure and function of proteins. With broader availability of experimental information on the occurrences of different PTM types, the investigation of a potential “crosstalk” between different PTM types and combinatorial effects have moved into ...
Korkuc, P., Walther, D.
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Bioinformatic Advancements in Post Translational Modifications (Ptms): An Experimental Approach [PDF]
, 2018 Tejpal Dhewa +3 more
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The role of ral signaling and post translational modifications (PTMs) of Ras in cancer
Genome Instability & Disease, 2022Mohammad Reza Zinatizadeh +4 more
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