Results 41 to 50 of about 503,764 (302)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
The survival and resurrection of a “Bakema-experiment” in an Amsterdam garden city
Docomomo Journal, 2021 There is a hidden gem in the Amsterdam garden cities. Jaap Bakema was the founder of an experiment in the 1950s. A piece of “Rotterdam in Amsterdam.” Based on the philosophy of an open society and the human scale.
Tim Nagtegaal
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
President Alemán Urban Housing Project
Docomomo Journal, 2021 The Centro Urbano Presidente Alemán, inaugurated in 1949, was a pioneer in more ways than one and can be considered as one of the most transcendent works of Mario Pani.
Louise Noelle
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Urban Planning, 2019 Three essential elements of modernism consolidated through war: a centralised welfare state, a serial industrial apparatus and, often, a territorial tabula rasa.
Gérald Ledent
doaj +1 more source
The Death of a Client: The End of The English Housing Estate [PDF]
, 2016 Journal article with photographs by author, exploring the political project behind the post-war housing estates of London using the exemplary projects in the London Borough of Camden as a case study. The article takes two well-known projects by architect
Hughes, Beth
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
And, 2022 Il 28 febbraio 1949 il Parlamento italiano rende legge il progetto Provvedimenti per incrementare l’occupazione operaia, agevolando la costruzione di case per lavoratori, presentato al Consiglio nel luglio dell’anno precedente dal ministro democristiano
Valter Scelsi
doaj
Evacuation, Hygiene, and Social Policy: The Our Towns Report of 1943. [PDF]
, 1999 There has recently been much debate about social policy in Britain during the Second World War. This article takes up Jose Harris's suggestion that historians should look not at large-scale forces, but at ‘those minuscule roots of idiosyncratic private ...
Welshman, John
core +1 more source