Results 161 to 170 of about 2,079,695 (308)

Sperm performance of coastal northern pike (<i>Esox lucius L.</i>) from the Baltic Sea shows no impairment between freshwater and brackish conditions. [PDF]

Conserv Physiol
Viving A, Ek C, Ogonowski M, Näslund J, Dahlgren E, Fitzpatrick JL, Daupagne L.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Persistent immune dysfunction during suppressive antiretroviral therapy: implications for analytical treatment interruption trials for chronic HIV infections in sub-Saharan Africa. [PDF]

Front Immunol
Kankundiye P, Kia P, Kankaka E, Nabatanzi R, Mahmoudi T, Nakanjako D.   +5 more
europepmc   +1 more source

Post Activation Potentiation Effect of Different Preloading Protocols on Sprint Performance

Abstract This study aimed to investigate the post-activation potentiation effects of different pre-loading protocols involving blood flow-restricted plyometric jumps on sprint performance. In this randomized crossover experimental study, 15 athletes with at least seven years of sporting experience participated voluntarily.
Çelik, Seyfullah, Erikoğlu Örer, Gamze   +1 more
openaire   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

From diet to brain repair: natural bioactive compounds in post-ischemic stroke recovery. [PDF]

Front Nutr
Bu F, Zhang Z, Qi S, Xu L.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Octreotide Counteracts IFN-γ-Induced Endothelial Inflammation. [PDF]

J Biochem Mol Toxicol
Fakir S, Sigdel M, Sarker MMR, Barabutis N.   +3 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The Effect of Cluster Sets and Accentuated Eccentric Loading on Vertical Jump Performance and Strategy During Lower-Body Complex Training. [PDF]

Eur J Sport Sci
Chae S, Jukic I, Merrigan JJ, Smith JC.
europepmc   +1 more source